Clinical Trials

Carboplatin is currently evaluated in numerous clinical trials spanning early- to late-phase development across a broad spectrum of oncological indications, including non-small cell lung cancer, ovarian carcinoma, metastatic breast cancer, head and neck cancer, and metastatic castration-resistant prostate cancer. Sponsored by academic institutions, cooperative research groups, and industry partners, these studies encompass active, recruiting, and completed protocols. Additionally, several clinical trials focus on combination regimens for resectable lung cancer and metastatic breast cancer.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07591467 NOT_YET_RECRUITING
BRCA-Mutated; Neuroendocrine-Differentiated Aggressive Metastatic Castration-Sensitive Prostate Cancer; Prostate Cancer
Gustave Roussy, Cancer Campus, Grand Paris
2026-09 PHASE3
NCT04198766 RECRUITING
Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma; Resectable Non-Small-Cell Lung Cancer
Inhibrx Biosciences, Inc
2019-12-10 PHASE1; PHASE2
NCT07346196 NOT_YET_RECRUITING
Squamous Cell Carcinoma
University of Chicago
2027-02-07 PHASE2
NCT07063745 RECRUITING
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb
2026-01-02 PHASE2; PHASE3
NCT07738315 NOT_YET_RECRUITING
Endometrial Carcinoma
Women's Hospital School Of Medicine Zhejiang University
2026-08-01 PHASE2
NCT01042379 RECRUITING
Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer
QuantumLeap Healthcare Collaborative
2010-03-01 PHASE2
NCT07001618 RECRUITING
NSCLC (Advanced Non-small Cell Lung Cancer)
Gustave Roussy, Cancer Campus, Grand Paris
2025-11-17 PHASE2
NCT05983276 RECRUITING
Ovarian Cancer
Loyola University
2023-11-16 PHASE2
NCT07709585 NOT_YET_RECRUITING
Advanced Non-small Cell Lung Cancer (NSCLC); EGFR Exon 19 Deletion Mutation; EGFR Exon 21 Mutation; EGFR Exon 21 L858R Mutation
Guangzhou University of Traditional Chinese Medicine
2026-07-05 PHASE2
NCT06561386 RECRUITING
Non-small Cell Lung Cancer
Bristol-Myers Squibb
2024-10-07 PHASE3
NCT06990516 NOT_YET_RECRUITING
Ovarian Cancer
Tongji Hospital
2025-06-01 PHASE1; PHASE2
NCT07290621 RECRUITING
Oropharyngeal Cancer
University of Chicago
2026-02 PHASE2
NCT06890338 RECRUITING
Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Neoadjuvant
AbbVie
2025-11-21 PHASE2
NCT07739199 NOT_YET_RECRUITING
Squamous Non-small-cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
2026-08 PHASE2; PHASE3
NCT04665206 RECRUITING
Solid Tumor, Adult; Mesothelioma; NSCLC
Vivace Therapeutics, Inc
2021-03-24 PHASE1; PHASE2
NCT06647563 NOT_YET_RECRUITING
Squamous Cell Carcinoma of Head and Neck
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2024-11-01 PHASE3
NCT05905315 RECRUITING
Locally Advanced Vulvar Carcinoma; Squamous Cell Carcinoma of the Vulva
The Netherlands Cancer Institute
2024-01-01 PHASE2
NCT06528496 RECRUITING
High-risk Neuroblastoma; Neuroblastoma; Childhood Neuroblastoma
Memorial Sloan Kettering Cancer Center
2024-07-22 PHASE2
NCT06953323 RECRUITING
Advanced Solid Tumor
Wigen Biomedicine Technology (Shanghai) Co., Ltd.
2025-07-10 PHASE1; PHASE2
NCT07276399 RECRUITING
Squamous Cell Carcinoma of Head and Neck
Janssen Research & Development, LLC
2025-12-03 PHASE3
NCT07129993 RECRUITING
Urothelial Cancer; Bladder Cancer
Daiichi Sankyo
2025-09-26 PHASE2; PHASE3
NCT06245889 RECRUITING
Triple Negative Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2024-05-01 PHASE2
NCT06632327 ACTIVE_NOT_RECRUITING
Resectable Lung Non-Small Cell Carcinoma; Stage II Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8
Alliance for Clinical Trials in Oncology
2024-12-11 PHASE3
NCT06771154 NOT_YET_RECRUITING
Recurrent/Metastatic Endometrial Cancer
Peking Union Medical College Hospital
2025-04-01 PHASE2
NCT07098988 RECRUITING
Metastatic Non-Squamous Non-Small Cell Lung Cancer; Adult Solid Tumor
CatalYm GmbH
2025-08-01 PHASE2
NCT06323369 RECRUITING
Head and Neck Squamous Cell Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-03-25 PHASE2
NCT07661173 NOT_YET_RECRUITING
Non Small Cell Lung Cancer
Anhui Provincial Cancer Hospital
2026-06-06 PHASE2
NCT07463313 NOT_YET_RECRUITING
Thymoma and Thymic Carcinoma
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
2026-03 PHASE2; PHASE3
NCT06996782 RECRUITING
Advanced or Metastatic Non-small Cell Lung Cancer
AstraZeneca
2025-11-24 PHASE1; PHASE2
NCT07106762 RECRUITING
Urothelial Cancer
Bristol-Myers Squibb
2025-09-30 PHASE2; PHASE3
NCT07610525 NOT_YET_RECRUITING
Triple Negative Breast Cancer; Blood and Image Guided; Optimization of Neoadjuvant Therapy; Phase 2
M.D. Anderson Cancer Center
2026-11-05 PHASE2
NCT06712316 RECRUITING
Non-small Cell Lung Cancer
BioNTech SE
2025-01-07 PHASE2; PHASE3
NCT07023484 RECRUITING
Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma
The University of Hong Kong
2025-05-22 PHASE2
NCT07622797 RECRUITING
Late-stage Resectable Esophageal Squamous Carcinoma
The First Affiliated Hospital of Henan University of Science and Technology
2025-11-21 PHASE2
NCT07622186 RECRUITING
Non-Small Cell Lung Cancer
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
2026-07-15 PHASE2
NCT07100080 RECRUITING
Non-Small Cell Lung Cancer
Bristol-Myers Squibb
2025-11-05 PHASE2; PHASE3
NCT05009082 RECRUITING
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
AGO Study Group
2022-09-13 PHASE3
NCT07028281 RECRUITING
Malignant Solid Tumors
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
2025-07-08 PHASE2
NCT06535607 RECRUITING
Sub-study 1 Cervical Cancer (Volrustomig Monotherapy); Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy); Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy); Sub-study 4 Esophageal Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy); Sub-study 5 Unresectable Pleural Mesothelioma (Volrustomig Monotherapy)
AstraZeneca
2024-08-22 PHASE2
NCT07181499 RECRUITING
NSCLC; Adjuvant Drug Therapy; EGFR
Betta Pharmaceuticals Co., Ltd.
2025-09 PHASE2
NCT07213804 RECRUITING
Ovarian Neoplasms; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Neoplasm Metastasis
Eli Lilly and Company
2025-10-22 PHASE3
NCT07016399 RECRUITING
Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Triple-Negative Breast Carcinoma
Vandana Abramson
2025-09-09 PHASE2
NCT06699212 RECRUITING
Recurrent Head and Neck Squamous Cell Carcinoma
Rakuten Medical, Inc.
2024-12-24 PHASE3
NCT06393816 RECRUITING
Large Cell Neuroendocrine Carcinoma of the Lung
Centre Leon Berard
2024-06-13 PHASE2
NCT06663098 RECRUITING
Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Gruppo Oncologico Italiano di Ricerca Clinica
2025-01-24 PHASE2
NCT06204614 ENROLLING_BY_INVITATION
Muscle Invasive Bladder Urothelial Carcinoma
Brigham and Women's Hospital
2024-06-14 EARLY_PHASE1
NCT07559929 NOT_YET_RECRUITING
Small Cell Lung Cancer
Hangzhou DAC Biotechnology Co., Ltd.
2026-06-01 PHASE1; PHASE2
NCT04811703 RECRUITING
Metastatic Ovarian Carcinoma; Peritoneal Carcinomatosis; Stage III Ovarian Cancer; Stage IV Ovarian Cancer; Stage III Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Metastatic Malignant Neoplasm in the Peritoneum
Hospices Civils de Lyon
2021-07-30 PHASE1
NCT05502237 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Gilead Sciences
2022-10-12 PHASE3
NCT06084845 WITHDRAWN
Head and Neck Squamous Cell Carcinoma; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Oral Cavity Cancer AJCC v8; Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
ECOG-ACRIN Cancer Research Group
2024-04-12 PHASE2
NCT05472220 WITHDRAWN
Solid Tumors, Adult; PIK3CA Mutation-Related Tumors; PIK3CA Mutation; Human Papillomavirus-Related Carcinoma; HPV-Related Squamous Cell Carcinoma; Human Papillomavirus-Related Squamous Cell Carcinoma; Locally Advanced Malignant Solid Neoplasm; Metastatic Malignant Solid Neoplasm
Pamela Munster
2022-11-01 PHASE1
NCT07383116 NOT_YET_RECRUITING
Non Squamous Non-small Cell Lung Cancer
Shanghai Huaota Biopharmaceutical Co., Ltd.
2026-01-15 PHASE3
NCT06926868 RECRUITING
Breast Neoplasms
Bristol-Myers Squibb
2025-09-11 PHASE2; PHASE3
NCT05684276 ACTIVE_NOT_RECRUITING
NSCLC; Pancoast Tumor
Fundación GECP
2023-05-12 PHASE2
NCT05902169 RECRUITING
Glioblastoma; Recurrent Glioblastoma; GBM
CarThera
2024-01-29 PHASE3
NCT06771622 ACTIVE_NOT_RECRUITING
Solid Cancer
FBD Biologics Limited
2025-03-13 PHASE1; PHASE2
NCT06464068 RECRUITING
Extrapulmonary Small Cell Carcinoma
Gruppo Oncologico Italiano di Ricerca Clinica
2024-01-16 PHASE2
NCT01154920 ACTIVE_NOT_RECRUITING
Head and Neck Squamous Cell Carcinoma
M.D. Anderson Cancer Center
2010-07-09 PHASE2
NCT07244978 NOT_YET_RECRUITING
Esophageal Squamous Cell Carcinoma; Neoadjuvant Therapy
Second Affiliated Hospital, Zhejiang University, School of Medicine
2026-06-01 PHASE2
NCT07401654 NOT_YET_RECRUITING
Ovarian Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2026-01-31 PHASE2
NCT02726997 ACTIVE_NOT_RECRUITING
Stage III Fallopian Tube Cancer AJCC v7; Stage III Ovarian Cancer AJCC v6 and v7; Stage III Primary Peritoneal Cancer AJCC v7; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
M.D. Anderson Cancer Center
2016-07-06 PHASE1; PHASE2
NCT07761429 RECRUITING
Cancer of Unknown Primary Site
Shandong New Time Pharmaceutical Co., LTD
2026-07-08 PHASE2; PHASE3
NCT07311577 RECRUITING
Ovarian Cancer Metastatic; Ovarian Cancer Metastatic Recurrent
Jiangsu Cancer Institute & Hospital
2026-01-01 PHASE2
NCT07172412 NOT_YET_RECRUITING
Extensive Stage Lung Small Cell Cancer
Tianjin Medical University Cancer Institute and Hospital
2025-11 PHASE2
NCT05652686 RECRUITING
Small Cell Lung Cancer (SCLC); Large Cell Neuroendocrine Cancer (LCNEC); Neuroendocrine Prostate Cancer (NEPC); Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC); Neuroendocrine Carcinomas (NEC); Extrapulmonary Neuroendocrine Carcinoma (EP-NEC)
Phanes Therapeutics
2023-09-05 PHASE1; PHASE2
NCT07220135 RECRUITING
Breast Cancer
University of Kansas Medical Center
2025-11-14 PHASE2
NCT07241767 RECRUITING
Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
2025-11-12 PHASE2
NCT05599984 ACTIVE_NOT_RECRUITING
Advanced Solid Tumors
AbbVie
2022-12-05 PHASE1
NCT05256225 RECRUITING
Endometrial Carcinoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Dedifferentiated Carcinoma; Endometrial Endometrioid Adenocarcinoma; Endometrial Mixed Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Endometrial Undifferentiated Carcinoma; Uterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor
National Cancer Institute (NCI)
2022-11-16 PHASE3
NCT07009457 ACTIVE_NOT_RECRUITING
Widespread Small Cell Lung Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
2025-06-16 PHASE1
NCT05487391 RECRUITING
Carcinoma, Non-Small-Cell Lung
Qilu Pharmaceutical Co., Ltd.
2022-12-08 PHASE3
NCT07061535 RECRUITING
Extensive-stage Small Cell Lung Cancer (ES-SCLC); Extensive Stage Lung Small Cell Cancer; Extensive-Stage Small-Cell Lung Cancer; Extensive Disease Small Cell Lung Cancer
Second Affiliated Hospital, Zhejiang University, School of Medicine
2025-07-30 PHASE2
NCT06057038 ACTIVE_NOT_RECRUITING
Malignant Solid Tumor
Genmab
2023-11-24 PHASE1
NCT05198830 ACTIVE_NOT_RECRUITING
Lung Adenocarcinoma; Lung Large Cell Carcinoma; Lung Non-Squamous Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8
National Cancer Institute (NCI)
2022-12-15 PHASE2
NCT07137858 NOT_YET_RECRUITING
Oral Squamous Cell Carcinoma (OSCC); Neoadjuvant Chemoimmunotherapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2025-08-15 PHASE2
NCT05420454 RECRUITING
Breast Cancer
Second Affiliated Hospital, Zhejiang University, School of Medicine
2022-07-10 PHASE4
NCT04999761 RECRUITING
Advanced or Metastatic Solid Tumor; Pancreatic Ductal Adenocarcinoma; Colorectal Cancer; Non-small Cell Lung Cancer; Gastric Cancer; Alveolar Soft Part Sarcoma; Esophageal Cancer; Head and Neck Cancer; Biliary Tract Cancer
Taiho Pharmaceutical Co., Ltd.
2021-06-01 PHASE1
NCT02341989 ACTIVE_NOT_RECRUITING
Testicular Neoplasms; Seminoma
St. Olavs Hospital
2015-04-08 PHASE3
NCT02297217 RECRUITING
Esophageal Cancer
AHS Cancer Control Alberta
2019-11-21 PHASE2
NCT06375109 NOT_YET_RECRUITING
Limited-stage Small-cell Lung Cancer
Beijing Chest Hospital, Capital Medical University
2024-04-16 PHASE2
NCT06407310 NOT_YET_RECRUITING
Triple Negative Breast Cancer
Tel Aviv Medical Center
2024-07-01 PHASE2
NCT07059221 RECRUITING
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
2025-07-11 PHASE1; PHASE2
NCT06727565 ACTIVE_NOT_RECRUITING
Head and Neck Squamous Cell Carcinoma
Gilead Sciences
2025-02-18 PHASE2
NCT07493980 NOT_YET_RECRUITING
NSCLC Stage II
Shanghai Pulmonary Hospital, Shanghai, China
2026-03 PHASE2
NCT04460352 RECRUITING
Esophageal Squamous Cell Carcinoma
Karolinska University Hospital
2020-11-27 PHASE3
NCT02955082 ACTIVE_NOT_RECRUITING
Hormone Refractory Prostate Cancer
Institute of Cancer Research, United Kingdom
2017-05-25 PHASE2
NCT06751277 NOT_YET_RECRUITING
Recurrent or Metastatic Endometrial Cancer
xiang yang
2025-02-01 PHASE2
NCT06157827 RECRUITING
Advanced Neuroendocrine Carcinoma
Nanjing Leads Biolabs Co.,Ltd
2023-12-08 PHASE1; PHASE2
NCT06652048 RECRUITING
Non-Small Cell Lung Cancer
Jialei Wang
2024-10-01 PHASE2
NCT07136285 RECRUITING
SCLC, Extensive Stage
Newsoara HYK Biopharmaceutical (Shanghai) Co., Ltd.
2023-07-24 PHASE1; PHASE2
NCT06943820 RECRUITING
Non-small Cell Lung Cancer Stage IIIB/IV; Head and Neck Squamous Cell Carcinoma (HNSCC); Colorectal Adenocarcinoma; Advanced Solid Tumors
Akeso
2025-05-21 PHASE1; PHASE2
NCT06704620 NOT_YET_RECRUITING
Advanced and Metastatic NSCLC
Tianjin Medical University Cancer Institute and Hospital
2024-12 PHASE3
NCT02962063 ACTIVE_NOT_RECRUITING
Esophageal Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma
Memorial Sloan Kettering Cancer Center
2016-11 PHASE1; PHASE2
NCT04162015 ACTIVE_NOT_RECRUITING
Malignant Pleural Mesothelioma
Memorial Sloan Kettering Cancer Center
2019-11-12 PHASE1
NCT04129502 ACTIVE_NOT_RECRUITING
Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Takeda
2020-01-10 PHASE3
NCT06303713 ACTIVE_NOT_RECRUITING
Prostate Cancer; Metastatic Prostate Cancer; Metastatic Castration-resistant Prostate Cancer
Dana-Farber Cancer Institute
2024-05-22 PHASE1
NCT06447662 ACTIVE_NOT_RECRUITING
Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung
Pfizer
2024-06-27 PHASE1
NCT06362252 RECRUITING
Extensive Stage-small Cell Lung Cancer
Daiichi Sankyo
2024-07-22 PHASE1; PHASE2
NCT05116462 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd.
2024-03-15 PHASE3
NCT05186974 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Gilead Sciences
2022-05-30 PHASE2
NCT07125391 RECRUITING
Ovarian Cancer
Bai-Rong Xia
2025-06-20 PHASE2
NCT04339218 RECRUITING
Lung Adenocarcinoma; Cryotherapy Effect
Institut Bergonié
2020-08-28 PHASE3
NCT04966663 RECRUITING
Non Small Cell Lung Cancer; Complete Surgical Resection; Circulating Tumor DNA
University Health Network, Toronto
2022-03-28 PHASE2
NCT05351788 RECRUITING
Non-small Cell Lung Cancer
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
2022-05-20 PHASE2
NCT04304248 UNKNOWN
Non Small Cell Lung Cancer
Hao Long
2019-08-01 PHASE2
NCT06911606 RECRUITING
SCLC, Limited Stage
Guangdong Provincial People's Hospital
2024-05-22 PHASE2
NCT05298423 COMPLETED
Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
2022-05-03 PHASE3
NCT04862650 ACTIVE_NOT_RECRUITING
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Metastatic Head and Neck Squamous Cell Carcinoma; Metastatic Hypopharyngeal Squamous Cell Carcinoma; Metastatic Laryngeal Squamous Cell Carcinoma; Metastatic Oral Cavity Squamous Cell Carcinoma; Metastatic Oropharyngeal Squamous Cell Carcinoma; Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Recurrent Head and Neck Squamous Cell Carcinoma; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral Cavity Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Squamous Cell Carcinoma of Unknown Primary; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Oral Cavity Cancer AJCC v8; Stage IVA Hypopharyngeal Carcinoma AJCC v8; Stage IVA Laryngeal Cancer AJCC v8; Stage IVA Lip and Oral Cavity Cancer AJCC v8; Stage IVB Hypopharyngeal Carcinoma AJCC v8; Stage IVB Laryngeal Cancer AJCC v8; Stage IVB Lip and Oral Cavity Cancer AJCC v8; Stage IVC Hypopharyngeal Carcinoma AJCC v8; Stage IVC Laryngeal Cancer AJCC v8; Stage IVC Lip and Oral Cavity Cancer AJCC v8
Marcelo Bonomi
2021-11-30 PHASE2
NCT04015778 ACTIVE_NOT_RECRUITING
Non Small Cell Lung Cancer
Guangdong Association of Clinical Trials
2019-08-08 PHASE2
NCT07365410 NOT_YET_RECRUITING
Non-small Cell Lung Cancer (NSCLC); Brain Metastases; Furmonertinib; EGFR Mutation
Tianjin Medical University Cancer Institute and Hospital
2026-01 PHASE2
NCT06980545 NOT_YET_RECRUITING
Stage III and IV Ovarian Cancer
Assiut University
2025-06-30 PHASE3
NCT06897579 TERMINATED
Extensive Stage Small Cell Lung Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
2025-04-07 PHASE2
NCT04638582 TERMINATED
Lung Cancer, Nonsmall Cell
McGill University Health Centre/Research Institute of the McGill University Health Centre
2022-08-28 PHASE2
NCT05743270 WITHDRAWN
Squamous Cell Carcinoma of Head and Neck; Locally Advanced Head and Neck Squamous Cell Carcinoma; Recurrent Head and Neck Squamous Cell Carcinoma
Replimune, Inc.
2024-01-30 PHASE2
NCT05117476 ACTIVE_NOT_RECRUITING
Advanced Solid Tumor; NSCLC
Cullinan Therapeutics Inc.
2021-10-29 PHASE1
NCT05468489 ACTIVE_NOT_RECRUITING
Extensive Stage Small Cell Lung Cancer
Shanghai Henlius Biotech
2022-11-18 PHASE3
NCT04147351 COMPLETED
NSCLC Stage IIIB~IV
National Taiwan University Hospital
2020-04-10 PHASE2
NCT05501665 RECRUITING
Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage III Lung Cancer
Vanderbilt-Ingram Cancer Center
2023-05-09 PHASE1; PHASE2
NCT03781986 ACTIVE_NOT_RECRUITING
Malignant Salivary Gland Cancer; Salivary Gland Cancer
University of Michigan Rogel Cancer Center
2019-10-28 PHASE1; PHASE2
NCT05668988 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Dizal Pharmaceuticals
2022-12-13 PHASE3
NCT03203590 UNKNOWN
2-year Disease-Free Survival
Sun Yat-sen University
2017-09 PHASE3
NCT03919552 RECRUITING
Cisplatin; Carboplatin; NPC
Nanfang Hospital, Southern Medical University
2018-01-31 PHASE3
NCT03623776 WITHDRAWN
Efficacy and Safety
Sun Yat-sen University
2019-02-01 PHASE2
NCT03582475 ACTIVE_NOT_RECRUITING
Bladder Small Cell Neuroendocrine Carcinoma; Castration-Resistant Prostate Carcinoma; Metastatic Bladder Urothelial Carcinoma; Metastatic Urethral Urothelial Carcinoma; Prostate Carcinoma Metastatic in the Bone; Prostate Neuroendocrine Neoplasm; Prostate Small Cell Carcinoma; Stage III Bladder Cancer American Joint Committee on Cancer ( AJCC) v8; Stage III Prostate Cancer AJCC v8; Stage III Urethral Cancer AJCC v8; Stage IV Bladder Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IV Urethral Cancer AJCC v8; Stage IVA Bladder Cancer AJCC v8; Stage IVB Bladder Cancer AJCC v8; Ureter Small Cell Carcinoma; Urothelial Carcinoma
Jonsson Comprehensive Cancer Center
2019-01-11 PHASE1
NCT06659042 RECRUITING
Lung Cancer, Non-Small Cell
Shanghai Chest Hospital
2024-11-20 PHASE2
NCT06164327 UNKNOWN
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
BeBetter Med Inc
2023-12-01 PHASE1
NCT04649385 COMPLETED
Advanced Solid Tumor
BeiGene
2021-03-04 PHASE1
NCT03036488 COMPLETED
Triple Negative Breast Neoplasms
Merck Sharp & Dohme LLC
2017-03-07 PHASE3
NCT03520686 TERMINATED
Non Small Cell Lung Cancer
ImmunityBio, Inc.
2018-05-18 PHASE3
NCT06574763 UNKNOWN
Ovarian Cancer
Sun Yat-sen University
2024-09-01 PHASE2
NCT05374512 ACTIVE_NOT_RECRUITING
Breast Cancer
AstraZeneca
2022-05-16 PHASE3
NCT05930665 UNKNOWN
Pleural Mesothelioma
Sun Yat-sen University
2023-11-01 PHASE2
NCT03918278 COMPLETED
Neoplasms
Merck Sharp & Dohme LLC
2019-06-19 PHASE1
NCT04046575 ACTIVE_NOT_RECRUITING
Esophagus Cancer; Esophageal Cancer; Cancer of the Esophagus
Washington University School of Medicine
2019-11-07 PHASE1
NCT02520154 COMPLETED
Stage III Fallopian Tube Cancer AJCC v7; Stage III Ovarian Cancer AJCC v6 and v7; Stage III Primary Peritoneal Cancer AJCC v7; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
M.D. Anderson Cancer Center
2016-07-05 PHASE2
NCT02429687 RECRUITING
Ovarian Germ Cell Cancer; Ovarian Neoplasms; Ovarian Cancer
Beihua Kong
2015-04 PHASE3
NCT03088540 COMPLETED
Carcinoma,Non-Small-Cell Lung; Lung Carcinomas, Non-Small-Cell; Non-small-cell Lung Carcinoma; Nonsmall Cell Lung Cancer
Regeneron Pharmaceuticals
2017-05-29 PHASE3
NCT06396065 ACTIVE_NOT_RECRUITING
Non-Squamous Non-small Cell Lung Cancer
Summit Therapeutics
2023-05-04 PHASE3
NCT06087289 COMPLETED
Epithelial Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
Novakand Pharma AB
2023-04-26 PHASE1; PHASE2
NCT04832854 TERMINATED
Non-Small Cell Lung Cancer (NSCLC)
Hoffmann-La Roche
2021-04-23 PHASE2
NCT04222972 TERMINATED
RET-fusion Non Small Cell Lung Cancer; Lung Neoplasm; Carcinoma, Non-Small-Cell Lung; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Disease; Carcinoma, Bronchogenic; Bronchial Diseases; Head and Neck Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms by Histologic Type; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue
Hoffmann-La Roche
2020-07-24 PHASE3
NCT06355024 COMPLETED
Triple-negative Breast Cancer
Fudan University
2024-05-11 PHASE2
NCT04617756 RECRUITING
Urothelial Carcinoma; Cancer
Centre Hospitalier Universitaire de Nīmes
2021-09-29 PHASE2
NCT04547907 RECRUITING
Breast Cancer,HER2-positive
Henan Cancer Hospital
2020-09-18 PHASE3
NCT05312840 COMPLETED
Non Small Cell Lung Cancer
People's Hospital of Quzhou
2022-01-01 PHASE4
NCT04856176 TERMINATED
Advanced Lung Non-Small Cell Carcinoma; Non-Small Cell Carcinoma of Lung, TNM Stage 4
Tufts Medical Center
2022-01-03 PHASE2
NCT06016413 NOT_YET_RECRUITING
Head and Neck Squamous Cell Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2023-09-01 PHASE2
NCT06237257 UNKNOWN
Locally Advanced Cervical Cancer
Shanghai Shengdi Pharmaceutical Co., Ltd
2024-03-20 PHASE2
NCT01706120 UNKNOWN
Ovarian Cancer
National Cancer Institute, Naples
2012-10 PHASE4
NCT02794571 COMPLETED
Advanced/Metastatic Tumors
Genentech, Inc.
2016-05-23 PHASE1
NCT05900921 UNKNOWN
Advanced Squamous Non-Small-Cell Lung Cancer
Sichuan University
2023-07-01 PHASE2
NCT02584478 UNKNOWN
Endometrial Carcinoma; Ovarian Carcinoma; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Cervical Carcinoma
Advenchen Laboratories, LLC
2015-12 PHASE3
NCT01149083 COMPLETED
Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Breast Carcinoma; Metastatic Breast Carcinoma; Unresectable Breast Carcinoma
National Cancer Institute (NCI)
2010-06-30 PHASE2
NCT05756972 ACTIVE_NOT_RECRUITING
NSCLC
Biotheus Inc.
2023-06-26 PHASE2
NCT05543629 TERMINATED
Advanced Solid Tumors; Non-small Cell Lung Cancer
Bristol-Myers Squibb
2022-10-04 PHASE1; PHASE2
NCT03107182 COMPLETED
HPV-Related Squamous Cell Carcinoma; HNSCC
University of Chicago
2017-06-27 PHASE2
NCT06094296 TERMINATED
NSCLC
Bristol-Myers Squibb
2023-11-27 PHASE2
NCT05715840 UNKNOWN
Recurrent, or Metastatic Cervical Cancer With PD-L1 Positive (CPS≥1)
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
2023-01-31 PHASE3
NCT03393884 ACTIVE_NOT_RECRUITING
Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer
Imunon
2018-09-05 PHASE1; PHASE2
NCT02964013 COMPLETED
Neoplasms
Merck Sharp & Dohme LLC
2016-12-13 PHASE1
NCT03850067 COMPLETED
Small Cell Lung Carcinoma
Celgene
2019-03-12 PHASE1
NCT04269200 ACTIVE_NOT_RECRUITING
Endometrial Neoplasms
AstraZeneca
2020-05-05 PHASE3
NCT03390686 ACTIVE_NOT_RECRUITING
Lung Cancer; Non-small Cell Lung Cancer
Prestige Biopharma Limited
2019-11-15 PHASE3
NCT05132985 NOT_YET_RECRUITING
NSCLC; EGF-R Positive Non-Small Cell Lung Cancer
Liaoning Cancer Hospital & Institute
2022-01-01 PHASE2
NCT04967417 COMPLETED
Non-small Cell Lung Cancer
Samsung Medical Center
2022-05-26 PHASE2
NCT03574779 COMPLETED
Ovarian Neoplasms
Tesaro, Inc.
2018-11-15 PHASE2
NCT05572476 WITHDRAWN
Small Cell Lung Cancer; Platinum-Sensitive Lung Small Cell Carcinoma; Extensive-stage Small-cell Lung Cancer
Institut Bergonié
2023-10 PHASE2
NCT04799249 COMPLETED
TNBC - Triple-Negative Breast Cancer; Breast Cancer
G1 Therapeutics, Inc.
2021-05-14 PHASE3
NCT04063163 COMPLETED
Extensive Stage Small Cell Lung Cancer
Shanghai Henlius Biotech
2019-09-12 PHASE3
NCT06393816 Not yet recruiting
Large Cell Neuroendocrine Carcinoma of the Lung
Centre Leon Berard|Groupe Français de Pneumo-Cancérologie
2024-05 Phase 2
NCT06303713 Not yet recruiting
Prostate Cancer|Metastatic Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Dana-Farber Cancer Institute|Novartis
2024-05 Phase 1
NCT05846789 Recruiting
Metastatic Breast Cancer|Triple Negative Breast Cancer|Estrogen-receptor-low Breast Cancer
Kathy Miller|Genentech Inc.|Indiana University
2024-05 Phase 2
NCT04619797 COMPLETED
Non-small Cell Lung Cancer (NSCLC)
Hoffmann-La Roche
2020-12-15 PHASE2; PHASE3
NCT04526691 ACTIVE_NOT_RECRUITING
Advanced or Metastatic NSCLC
Daiichi Sankyo
2020-09-15 PHASE1
NCT05298176 COMPLETED
Non-Small Cell Lung Cancer
Amsterdam UMC, location VUmc
2022-01-04 PHASE2
NCT06288854 Not yet recruiting
Weight Gain
Rajavithi Hospital
2024-04-03 Not Applicable
NCT05872412 UNKNOWN
Triple Negative Breast Cancer
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
2023-06-01 PHASE2
NCT05367206 RECRUITING
Cervical Cancer; Neoadjuvant Chemotherapy; Bulky Neoplasm
Sun Yat-sen University
2022-03-14 PHASE3
NCT04524689 TERMINATED
Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC)
Sanofi
2020-10-26 PHASE2
NCT05611879 UNKNOWN
NSCLC, Stage III
Beijing Tsinghua Chang Gung Hospital
2023-03-12 PHASE2
NCT04868708 COMPLETED
Recurrent or Metastatic Cervical Cancer
Akeso
2021-04-01 PHASE2
NCT01847326 COMPLETED
Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Tongue Cancer
University of Chicago
2013-03-26 PHASE1
NCT04951115 TERMINATED
Small-cell Lung Cancer
Weill Medical College of Cornell University
2021-07-12 PHASE2
NCT05386888 COMPLETED
NSCLC, Stage III
Genfleet Therapeutics (Shanghai) Inc.
2022-09-09 PHASE2
NCT00980954 COMPLETED
Cervical Cancer
Radiation Therapy Oncology Group
2009-09 PHASE3
NCT05151549 UNKNOWN
Cervical Cancer
Hunan Cancer Hospital
2021-12-01 PHASE2
NCT00657878 UNKNOWN
Ovarian Cancer
National Cancer Institute, Naples
2008-11 PHASE3
NCT04440358 COMPLETED
Recurrent Glioblastoma
InSightec
2020-10-13 PHASE1; PHASE2
NCT04871529 TERMINATED
Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall; Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma; Stage II Bladder Cancer AJCC v8
SWOG Cancer Research Network
2022-08-10 PHASE2
NCT02501954 COMPLETED
Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Uterine Corpus Cancer; Stage IIIC Uterine Corpus Cancer; Stage IVA Uterine Corpus Cancer
Women's Cancer Care Associates, LLC
2015-03 PHASE3
NCT02436993 ACTIVE_NOT_RECRUITING
Breast Carcinoma
University of California, Irvine
2015-04 PHASE2
NCT04865289 COMPLETED
Endometrial Neoplasms
Merck Sharp & Dohme LLC
2019-10-22 PHASE3
NCT04981899 UNKNOWN
Hodgkin Lymphoma
St. Petersburg State Pavlov Medical University
2021-03-01 PHASE1; PHASE2
NCT03976362 COMPLETED
Carcinoma, Squamous Cell, Non-small-cell Lung
Merck Sharp & Dohme LLC
2019-06-28 PHASE3
NCT04923776 TERMINATED
Small-cell Lung Cancer
Brian Henick, MD
2021-09-20 PHASE2
NCT05030077 UNKNOWN
Urothelial Carcinoma; Anlotinib; Urogenital Neoplasms; Cisplatin; Carboplatin; Gemcitabine; Antineoplastic Agents
Tianjin Medical University Second Hospital
2021-10-01 PHASE2
NCT04238988 UNKNOWN
Locally Advanced Cervical Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2021-02-18 PHASE2
NCT04870112 TERMINATED
Non-Small Cell Lung Cancer; Small Cell Lung Cancer
AstraZeneca
2021-06-28 PHASE1
NCT04028050 COMPLETED
Small Cell Lung Carcinoma
Hoffmann-La Roche
2019-08-12 PHASE3
NCT03141359 ACTIVE_NOT_RECRUITING
Lung Cancer Stage II; Lung Cancer Stage III; Non Small Cell Lung Cancer
Wake Forest University Health Sciences
2017-05-12 PHASE2
NCT04770272 TERMINATED
Triple-negative Breast Cancer
Palleos Healthcare GmbH
2021-03-01 PHASE2
NCT04712903 COMPLETED
Small Cell Lung Carcinoma Extensive Disease
AstraZeneca
2020-12-16 PHASE3
NCT04840290 UNKNOWN
Non Small Cell Lung Cancer
Tang-Du Hospital
2019-06-01 PHASE3
NCT03289910 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Atypical Chronic Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Essential Thrombocythemia; Myelodysplastic/Myeloproliferative Neoplasm; Myelofibrosis; Polycythemia Vera; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
National Cancer Institute (NCI)
2018-09-24 PHASE2
NCT04005716 COMPLETED
Small Cell Lung Cancer
BeiGene
2019-07-22 PHASE3
NCT04815408 UNKNOWN
Ovarian Cancer; Neoadjuvant Chemotherapy; Anti-PD-1; Neoadjuvant Immunotherapy
Second Affiliated Hospital, Zhejiang University, School of Medicine
2021-04-01 PHASE2
NCT04846634 NOT_YET_RECRUITING
Resectable Locally Advanced Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
2021-08 PHASE2
NCT03515837 COMPLETED
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
2018-06-29 PHASE3
NCT04722718 UNKNOWN
Breast Cancer
Jiuda Zhao
2021-02-01 PHASE2
NCT05207904 UNKNOWN
Non-Small Cell Squamous Lung Cancer; Brain Metastases
Sun Yat-sen University
2021-06-17 PHASE2
NCT05318443 COMPLETED
Non-squamous Non-small-cell Lung Cancer
Shanghai Institute Of Biological Products
2020-04-17 PHASE3
NCT02629718 UNKNOWN
PFS; OS; Quality of Life
Sun Yat-sen University
2015-12 PHASE3
NCT03206203 COMPLETED
Triple Negative Breast Cancer; Stage IV Breast Cancer; HER2 Negative; Invasive Breast Cancer
Vanderbilt-Ingram Cancer Center
2017-08-29 PHASE2
NCT04422392 TERMINATED
Non Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
2020-07-13 PHASE2
NCT03965689 ACTIVE_NOT_RECRUITING
Metastatic Lung Non-Small Cell Squamous Carcinoma; Metastatic Lung Non-Squamous Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Lung Non-Squamous Non-Small Cell Carcinoma
National Cancer Institute (NCI)
2020-04-16 PHASE2
NCT04861948 TERMINATED
Solid Tumors; Lung Adenocarcinoma; Osteosarcoma
Innovent Biologics (Suzhou) Co. Ltd.
2021-05-25 PHASE1
NCT04022876 TERMINATED
Non Small Cell Lung Cancer; Small-cell Lung Cancer
Aileron Therapeutics, Inc.
2019-09-03 PHASE1
NCT03992911 UNKNOWN
Neuroendocrine Carcinoma of the Bladder
Peking University
2019-06-19 PHASE2; PHASE3
NCT04551950 COMPLETED
Cervical Cancer
EMD Serono Research & Development Institute, Inc.
2020-10-19 PHASE1
NCT04825938 NOT_YET_RECRUITING
Salivary Gland Malignant Neoplasms; Salivary Gland Tumors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2021-04-30 PHASE2
NCT03717415 TERMINATED
Locally Advanced or Metastatic Solid Tumor
Deciphera Pharmaceuticals, LLC
2019-01-02 PHASE1; PHASE2
NCT04405674 UNKNOWN
Non Small Cell Lung Cancer
Shanghai Chest Hospital
2020-07-15 PHASE2
NCT03674242 TERMINATED
Triple Negative Breast Cancer
ERYtech Pharma
2019-06-13 PHASE2; PHASE3
NCT04203485 UNKNOWN
PD-L1 Positive Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-06-15 PHASE3
NCT03737123 TERMINATED
Urothelial Carcinoma
Nabil Adra
2018-12-19 PHASE2
NCT04632342 UNKNOWN
Radiation Pneumonitis; Lung Cancer
Hanlim Pharm. Co., Ltd.
2020-11 PHASE2
NCT04470076 UNKNOWN
Non Small Cell Lung Cancer; Surgery; EGFR Activating Mutation; Chemotherapy; EGFR TKI
Fifth Affiliated Hospital, Sun Yat-Sen University
2020-07-10 PHASE2
NCT04902885 COMPLETED
Extensive-stage Small-cell Lung Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.
2021-05-25 PHASE3
NCT03713944 TERMINATED
NSCLC Stage IV; NSCLC, Recurrent
Nasser Hanna
2018-11-15 PHASE2
NCT02420314 COMPLETED
Carcinoma, Non-Small-Cell Lung
Joseph J. Cullen, MD, FACS
2015-04 PHASE2
NCT02617849 UNKNOWN
Metastatic Malignant Melanoma
Wilson Miller
2016-05-19 PHASE2
NCT04265534 TERMINATED
Non-Small Cell Lung Cancer; Non-squamous Non-small-cell Lung Cancer; Non-Squamous Non-Small Cell Neoplasm of Lung; KEAP1 Gene Mutation; NRF2 Gene Mutation; NFE2L2 Gene Mutation
Calithera Biosciences, Inc
2020-07-24 PHASE2
NCT02628405 UNKNOWN
Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Recurrent Transformed Non-Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Refractory Transformed Non-Hodgkin Lymphoma
Academic and Community Cancer Research United
2016-05-20 PHASE1; PHASE2
NCT04684017 UNKNOWN
SCLC; Anlotinib
Shanghai Chest Hospital
2019-05-01 PHASE2
NCT01779050 TERMINATED
Breast Neoplasms
Washington University School of Medicine
2013-12-19 PHASE2
NCT04108013 UNKNOWN
Lung Cancer Stage II; PD-1 Antibody; Non-small Cell Lung Cancer
Xuanwu Hospital, Beijing
2019-10-08 PHASE2
NCT03351361 COMPLETED
Advanced Non Small Cell Lung Cancer
Rennes University Hospital
2018-02-19 PHASE3
NCT04073537 UNKNOWN
Squamous Non-small Cell Lung Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
2019-10-31 PHASE3
NCT02822157 UNKNOWN
Ovarian Epithelial Cancer
Universitaire Ziekenhuizen KU Leuven
2016-08 PHASE2
NCT03744026 COMPLETED
Glioblastoma, Adult
CarThera
2019-02-18 PHASE1; PHASE2
NCT04470674 WITHDRAWN
Lung Cancer; Non-small Cell Lung Cancer; PD-L1 Gene Mutation; KRAS Activating Mutation
Shirish M Gadgeel
2021-04-06 PHASE2
NCT03295552 TERMINATED
Breast Neoplasm
Shanghai Jiao Tong University School of Medicine
2017-11-15 PHASE2
NCT03987867 UNKNOWN
Non-small Cell Lung Cancer; First-line Treatment
Tianjin Medical University Cancer Institute and Hospital
2019-06-01 PHASE1
NCT02445391 ACTIVE_NOT_RECRUITING
Estrogen Receptor Negative; HER2/Neu Negative; Invasive Breast Carcinoma; Progesterone Receptor Negative; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage III Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-Negative Breast Carcinoma
ECOG-ACRIN Cancer Research Group
2015-10-20 PHASE3
NCT03349346 WITHDRAWN
Diffuse Large B-Cell Lymphoma; Mediastinal B-cell Lymphoma
Gilead Sciences
2019-06 PHASE1
NCT03901378 WITHDRAWN
Neuroendocrine Carcinoma; Large Cell Neuroendocrine Carcinoma of the Lung; High Grade Neuroendocrine Carcinoma, Any Site
Ochsner Health System
2019-10-02 PHASE2
NCT02862457 COMPLETED
Neoplasms; Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
2016-08-23 PHASE1
NCT02025881 TERMINATED
High-risk Medulloblastoma
Gustave Roussy, Cancer Campus, Grand Paris
2013-09-14 PHASE1; PHASE2
NCT03717155 COMPLETED
Squamous Non-Small Cell Lung Cancer
Merck KGaA, Darmstadt, Germany
2018-10-30 PHASE2
NCT02580994 COMPLETED
Small Cell Lung Cancer (SCLC)
European Organisation for Research and Treatment of Cancer - EORTC
2017-12-08 PHASE2
NCT03394885 COMPLETED
Ovarian Cancer; Ovarian Neoplasms
Duke University
2018-06-19 PHASE1; PHASE2
NCT03912402 UNKNOWN
Cervical Cancer; Cervical Cancer Metastatic; Cervical Cancer Recurrent
Biocad
2018-12-25 PHASE2
NCT01372579 UNKNOWN
Estrogen Receptor-negative Breast Cancer; HER2-negative Breast Cancer; Male Breast Cancer; Progesterone Receptor-negative Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-negative Breast Cancer
Northwestern University
2011-08 PHASE2
NCT03117049 COMPLETED
Non-Small Cell Lung Cancer
Ono Pharmaceutical Co., Ltd.
2017-06-13 PHASE3
NCT03628521 UNKNOWN
Lung Cancer; Advanced Stage
Shanghai Chest Hospital
2018-07-20 PHASE1
NCT05169801 COMPLETED
Non-small Cell Lung Cancer(NSCLC)
Jiangsu HengRui Medicine Co., Ltd.
2018-01-25 PHASE3
NCT02177552 UNKNOWN
Esophageal Neoplasms; Stomach Neoplasms
Rigshospitalet, Denmark
2014-06 PHASE2
NCT00392327 COMPLETED
Anaplastic Medulloblastoma; Medulloblastoma
Children's Oncology Group
2007-05-23 PHASE3
NCT02044601 WITHDRAWN
Lung Cancer
M.D. Anderson Cancer Center
2014-06 PHASE1; PHASE2
NCT02116959 TERMINATED
Advanced Intra-Ocular Retinoblastoma; Retinoblastoma
University of California, San Francisco
2014-07-23 PHASE1
NCT03950674 COMPLETED
Non-Small-Cell Lung Carcinoma
Merck Sharp & Dohme LLC
2016-02-22 PHASE3
NCT02065687 UNKNOWN
Endometrial Adenocarcinoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Endometrial Undifferentiated Carcinoma; Recurrent Uterine Corpus Carcinoma; Stage III Uterine Corpus Cancer AJCC v7; Stage IIIA Uterine Corpus Cancer AJCC v7; Stage IIIB Uterine Corpus Cancer AJCC v7; Stage IIIC Uterine Corpus Cancer AJCC v7; Stage IV Uterine Corpus Cancer AJCC v7; Stage IVA Uterine Corpus Cancer AJCC v7; Stage IVB Uterine Corpus Cancer AJCC v7
Gynecologic Oncology Group
2014-03-17 PHASE2; PHASE3
NCT02186847 COMPLETED
Adenosquamous Lung Carcinoma; Bronchioloalveolar Carcinoma; Large Cell Lung Carcinoma; Lung Adenocarcinoma; Non-Small Cell Lung Carcinoma; Recurrent Non-Small Cell Lung Carcinoma; Squamous Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIB Non-Small Cell Lung Cancer
NRG Oncology
2014-08 PHASE2
NCT03058939 WITHDRAWN
Breast Cancer; Breast Cancer Stage II; Breast Cancer Stage III
University of Chicago
2018-11 PHASE2
NCT01966913 UNKNOWN
Germ Cell Tumor
Assistance Publique - Hôpitaux de Paris
2012-04 PHASE1; PHASE2
NCT03432598 COMPLETED
Locally Advanced Lung Cancer; Metastatic Lung Cancer
BeiGene
2017-08-24 PHASE2
NCT01490749 COMPLETED
Esophageal Cancer; Neoplasms, Esophageal
Emory University
2012-02 PHASE1
NCT03151161 UNKNOWN
Lung, Carcinoma
Sun Yat-sen University
2015-12 PHASE2
NCT02272790 COMPLETED
Ovarian, Fallopian Tube, Peritoneal Cancer, P53 Mutation
AstraZeneca
2015-01-30 PHASE2
NCT02686346 COMPLETED
Hodgkin Disease
The Lymphoma Academic Research Organisation
2016-03 PHASE1; PHASE2
NCT02453282 ACTIVE_NOT_RECRUITING
Non-Small-Cell Lung Carcinoma NSCLC
AstraZeneca
2015-07-21 PHASE3
NCT02744898 COMPLETED
Endometrial Cancer
NYU Langone Health
2016-07 PHASE2
NCT01367301 TERMINATED
Stage IA Uterine Sarcoma; Stage IB Uterine Sarcoma; Stage IC Uterine Sarcoma; Stage IIA Uterine Sarcoma; Stage IIB Uterine Sarcoma; Stage IIIA Uterine Sarcoma; Stage IIIB Uterine Sarcoma; Stage IIIC Uterine Sarcoma; Stage IVA Uterine Sarcoma; Stage IVB Uterine Sarcoma; Uterine Carcinosarcoma
Albert Einstein College of Medicine
2011-07-08
NCT03574649 WITHDRAWN
Non Small Cell Lung Cancer
ImmunityBio, Inc.
2018-06 PHASE2
NCT01185171 COMPLETED
Head and Neck Cancer
University of Chicago
2003-01-27 PHASE2
NCT02253212 COMPLETED
Glioblastoma; Glioma; Brain Tumor
Assistance Publique - Hôpitaux de Paris
2014-07 PHASE1; PHASE2
NCT02622074 COMPLETED
Triple Negative Breast Neoplasms
Merck Sharp & Dohme LLC
2016-01-27 PHASE1
NCT02126969 COMPLETED
Head and Neck Cancer; Larynx
Susanne Arnold
2014-10 PHASE2
NCT02407600 UNKNOWN
Non-small Cell Lung Cancer; Vomiting; Nausea; Emesis
Ajeet Gajra
2015-04 PHASE2
NCT01376310 TERMINATED
Cancer
Novartis Pharmaceuticals
2010-11-02 PHASE2
NCT02470468 COMPLETED
Stage IV Non-small Cell Lung Cancer
SOTIO a.s.
2014-12 PHASE1; PHASE2
NCT00997906 UNKNOWN
Head and Neck Cancer
National Cancer Centre, Singapore
2009-09-15 PHASE2; PHASE3
NCT00780494 COMPLETED
Stomach Cancer; Gastric (Stomach) Cancer; Neoplasm of Cardioesophageal Junction; Gastrointestinal Stromal Tumor (GIST)
Stanford University
2009-02 PHASE2
NCT01644955 COMPLETED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Recurrent Adult Brain Tumor
James Elder
2012-06-11 PHASE1
NCT02409355 TERMINATED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
2015-05-07 PHASE3
NCT02879097 UNKNOWN
Non-Small Cell Lung Carcinoma
Cipla BioTec Pvt. Ltd.
2016-12 PHASE3
NCT02424045 COMPLETED
T-cell Lymphoma
Samsung Medical Center
2015-05 PHASE2
NCT02051868 UNKNOWN
Squamous Cell Carcinoma of the Anus
Royal Marsden NHS Foundation Trust
2013-12 PHASE2
NCT02499770 COMPLETED
Small Cell Lung Cancer
G1 Therapeutics, Inc.
2015-06-26 PHASE1; PHASE2
NCT01654146 UNKNOWN
Ovarian Cancer
Medical Research Council
2011-06 PHASE3
NCT01169636 COMPLETED
Hodgkin's Lymphoma
M.D. Anderson Cancer Center
2011-01-31 PHASE1; PHASE2
NCT02219737 COMPLETED
CD20 Positive; Recurrent Diffuse Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma
National Cancer Institute (NCI)
2014-09-12 PHASE1
NCT01701349 WITHDRAWN
Anaplastic Thyroid Cancer
Mateon Therapeutics
2015-03 PHASE3
NCT01752686 UNKNOWN
Breast Cancer
Severance Hospital
2013-03 PHASE3
NCT01352962 COMPLETED
Urethral Neoplasms; Neoplasms, Urethral; Cancer of the Urethra; Urethral Cancer
National Cancer Institute (NCI)
2011-09-26 PHASE1
NCT01041781 TERMINATED
Lung Cancer
Alliance for Clinical Trials in Oncology
2010-02 PHASE3
NCT02106546 COMPLETED
Squamous Non-Small Cell Lung Cancer
AbbVie
2014-04-10 PHASE3
NCT02207361 UNKNOWN
Metastatic Breast Cancer
Tianjin Medical University Cancer Institute and Hospital
2013-12 PHASE4
NCT02207335 UNKNOWN
Metastatic Breast Cancer
Tianjin Medical University Cancer Institute and Hospital
2013-12 PHASE3
NCT00989651 COMPLETED
Fallopian Tube Carcinoma; Fallopian Tube Carcinosarcoma; Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Neoplasm; Fallopian Tube Transitional Cell Carcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Brenner Tumor; Ovarian Carcinoma; Ovarian Carcinosarcoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Seromucinous Tumor; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Ovarian Undifferentiated Carcinoma; Primary Peritoneal Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Stage IIA Fallopian Tube Cancer AJCC v6 and v7; Stage IIA Ovarian Cancer AJCC V6 and v7; Stage IIB Fallopian Tube Cancer AJCC v6 and v7; Stage IIB Ovarian Cancer AJCC v6 and v7; Stage IIC Fallopian Tube Cancer AJCC v6 and v7; Stage IIC Ovarian Cancer AJCC v6 and v7; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
National Cancer Institute (NCI)
2009-10-28 PHASE1
NCT01189968 COMPLETED
Non Small Cell Lung Cancer
OncoMed Pharmaceuticals, Inc.
2010-09 PHASE1
NCT00614822 COMPLETED
Non Small Cell Lung Cancer
Christiana Care Health Services
2007-11 PHASE2
NCT02161679 WITHDRAWN
Triple-negative Breast Cancer
Gilead Sciences
2016-08 PHASE2
NCT02319889 TERMINATED
Stage I Non-Small Cell Lung Cancer; Stage II Non-Small Cell Lung Cancer
Case Comprehensive Cancer Center
2016-02-02 EARLY_PHASE1
NCT01549093 UNKNOWN
Non-small Cell Lung Cancer
Hunan Province Tumor Hospital
2011-08 PHASE2
NCT01887340 UNKNOWN
Seminoma
Gustave Roussy, Cancer Campus, Grand Paris
2013-06 PHASE2
NCT00702572 TERMINATED
Non-small Cell Lung Cancer
Milton S. Hershey Medical Center
2008-04 PHASE1
NCT04031703 COMPLETED
Breast Cancer
Fudan University
2011-01-01 PHASE3
NCT01493843 COMPLETED
Non-Small Cell Lung Cancer
Genentech, Inc.
2012-01-20 PHASE2
NCT01256268 COMPLETED
Endometrial Cancer; Ovarian Cancer
H. Lee Moffitt Cancer Center and Research Institute
2011-06-13 PHASE1
NCT01702714 WITHDRAWN
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
2014-07 PHASE1
NCT01280058 COMPLETED
Pancreatic Acinar Cell Carcinoma; Pancreatic Ductal Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage IV Pancreatic Cancer
National Cancer Institute (NCI)
2010-12 PHASE2
NCT01191892 COMPLETED
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Ureter Cancer; Urethral Cancer
Cardiff University
2010-06 PHASE2
NCT01704287 COMPLETED
Malignant Melanoma
Merck Sharp & Dohme LLC
2012-11-20 PHASE2
NCT01496742 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Genentech, Inc.
2012-04 PHASE2
NCT00744718 COMPLETED
Ovarian Cancer
Vejle Hospital
2008-08 PHASE2
NCT01936974 TERMINATED
Ovarian Carcinoma; Fallopian Tube Carcinoma; Peritoneal Carcinoma
Western Regional Medical Center
2013-09 PHASE2
NCT01412229 COMPLETED
Head and Neck Cancer
UNC Lineberger Comprehensive Cancer Center
2012-02 PHASE2
NCT01555710 UNKNOWN
Extensive-Stage Small Cell Lung Cancer
Alaunos Therapeutics
2012-05 PHASE3
NCT02001896 UNKNOWN
Non-Small Cell Lung Cancer
Xinjiang Medical University
2013-12 PHASE3
NCT01331525 COMPLETED
Extensive Stage Small Cell Lung Cancer
University Hospital Southampton NHS Foundation Trust
2011-06 PHASE2
NCT01487915 UNKNOWN
Advanced Urothelial Carcinoma
Asan Medical Center
2010-10 PHASE2
NCT01450761 COMPLETED
Small Cell Lung Carcinoma
Bristol-Myers Squibb
2011-12-13 PHASE3
NCT01317615 COMPLETED
Carcinoma, Large Cell; Neuroendocrine Tumors
Novartis Pharmaceuticals
2011-04 PHASE4
NCT01815242 COMPLETED
Breast Cancer
Women's Cancer Study Group GmbH
2013-06 PHASE2
NCT00749723 COMPLETED
Recurrent Brain Tumors; Supratentorial PNETs; Medulloblastomas; Ependymomas
University Hospital, Bonn
2006-02-01 PHASE2; PHASE3
NCT01683682 COMPLETED
Carcinoma, Non-Small-Cell Lung
Aktion Bronchialkarzinom e.V.
2013-04 PHASE1
NCT00704639 COMPLETED
Head and Neck Cancer
Trans Tasman Radiation Oncology Group
2008-04 PHASE1; PHASE2
NCT01781988 COMPLETED
Lung Cancer; Carboplatin Adverse Reaction
Guangzhou Medical University
2009-06 PHASE2
NCT00021255 COMPLETED
Breast Neoplasms
Sanofi
2001-04 PHASE3
NCT00690872 UNKNOWN
Head and Neck Cancer
National Cancer Centre, Singapore
2008-07 PHASE2
NCT01309607 UNKNOWN
ErbB2-Positive Stage I-III Breast Cancer
National University Hospital, Singapore
2011-04 PHASE2
NCT01688791 TERMINATED
Advanced Cancer
Endocyte
2012-12 PHASE1
NCT00861705 COMPLETED
Male Breast Carcinoma; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7; Stage IIIA Breast Cancer AJCC v7; Triple-Negative Breast Carcinoma
National Cancer Institute (NCI)
2009-07-21 PHASE2
NCT00953420 COMPLETED
Nasopharyngeal Carcinoma
Baylor College of Medicine
2009-11 PHASE2
NCT01275664 TERMINATED
Nausea and Vomiting; Ovarian Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Cystadenocarcinoma; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Undifferentiated Ovarian Carcinoma
Gynecologic Oncology Group
2011-06
NCT01570582 UNKNOWN
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cancer
Korean Gynecologic Oncology Group
2010-03 PHASE2
NCT00317408 UNKNOWN
Lymphoma
European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma
2004-04
NCT00648648 COMPLETED
Solid Tumors
Merck Sharp & Dohme LLC
2008-02-25 PHASE1
NCT01463501 UNKNOWN
Esophageal Cancer
Zhejiang Cancer Hospital
2011-10 PHASE2
NCT01004172 COMPLETED
Metastatic Breast Cancer; Breast Cancer; Progressive Breast Cancer
Dana-Farber Cancer Institute
2009-11 PHASE2
NCT01236716 COMPLETED
Carcinoma, Non-Small-Cell Lung
Chinese Society of Lung Cancer
2010-11 PHASE2
NCT00321334 COMPLETED
Non-small Cell Lung Cancer
Chinese Society of Lung Cancer
2006-03 PHASE3
NCT00769470 COMPLETED
Breast Cancer
Translational Oncology Research International
2009-04 PHASE2
NCT01293630 COMPLETED
Advanced Solid Tumors
Sanofi
2011-01 PHASE1
NCT01268059 TERMINATED
Non-small Cell Lung Cancer
MedImmune LLC
2010-12-16 PHASE1; PHASE2
NCT01200342 TERMINATED
Melanoma
M.D. Anderson Cancer Center
2010-12 PHASE2
NCT00998192 COMPLETED
Metastatic or Recurrent Squamous Cell Carcinoma of the Lung
Oncolytics Biotech
2009-10 PHASE2
NCT01617928 COMPLETED
Solid Tumors
AbbVie (prior sponsor, Abbott)
2012-05 PHASE1
NCT00887575 COMPLETED
Breast Cancer
SCRI Development Innovations, LLC
2009-06 PHASE1; PHASE2
NCT00621049 COMPLETED
Non-Small Cell Lung Cancer
SCRI Development Innovations, LLC
2007-12 PHASE2
NCT01038037 TERMINATED
Non Small Cell Lung Cancer
Vejle Hospital
2010-01 PHASE2
NCT00147225 COMPLETED
Solid Tumors; Advanced Cancer
M.D. Anderson Cancer Center
2005-08 PHASE1; PHASE2
NCT01366131 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Genentech, Inc.
2011-06 PHASE2
NCT01542047 TERMINATED
Cancer, Metastatic
New Mexico Cancer Research Alliance
2012-08 PHASE1
NCT00927589 COMPLETED
Solid Cancers
Genentech, Inc.
2009-07 PHASE1
NCT00948675 COMPLETED
Advanced Non-Small Cell Lung Cancer
Eli Lilly and Company
2009-09-01 PHASE3
NCT01364012 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
2011-05-23 PHASE3
NCT00949247 COMPLETED
Breast Cancer
Case Comprehensive Cancer Center
2009-12 EARLY_PHASE1
NCT01527864 UNKNOWN
Non Small Cell Lung Cancer
Beijing Protgen Biotechnology Development Co., Ltd.
2011-05 PHASE2
NCT01531790 COMPLETED
Non-Small Cell Lung Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.
2011-09 PHASE1
NCT01242072 UNKNOWN
Malignancy; Cancer; Non Small Cell Lung Cancer; Small Cell Lung Cancer; Testicular Cancer; Thymoma; Ovarian Cancer; Osteosarcoma
Alaunos Therapeutics
2010-11 PHASE1
NCT01229930 COMPLETED
Cervical Cancer
University of Glasgow
2010-06 PHASE2
NCT01038752 TERMINATED
Non-small Cell Lung Cancer
Optimum Therapeutics, LLC
2010-08 PHASE2
NCT00960297 TERMINATED
Non-Small Cell Lung Cancer
SCRI Development Innovations, LLC
2009-08 PHASE2
NCT01234038 COMPLETED
Non-small Cell Lung Cancer
Ionis Pharmaceuticals, Inc.
2010-11 PHASE1; PHASE2
NCT00700180 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
2008-09 PHASE2
NCT00927875 COMPLETED
Small Cell Lung Carcinoma
Bristol-Myers Squibb
2010-02 PHASE1
NCT00255723 COMPLETED
Lymphoma
Memorial Sloan Kettering Cancer Center
2004-04 PHASE2
NCT01313663 TERMINATED
Lung Cancer, Small Cell
GlaxoSmithKline
2011-02 PHASE2
NCT00439361 COMPLETED
Hodgkin Lymphoma; Lymphoma
M.D. Anderson Cancer Center
2007-02 PHASE1
NCT00976183 TERMINATED
Ovarian Neoplasms
Gynecologic Oncology Associates
2009-10 PHASE1; PHASE2
NCT01151761 TERMINATED
Cholangiocarcinoma; Hepatobiliary Neoplasm; Liver Cancer; Bile Duct Cancer; Cancer of Gallbladder
Stanford University
2011-01 PHASE2
NCT00588666 COMPLETED
Myeloproliferative Disorder; Urothelial Carcinoma; Cancer
Memorial Sloan Kettering Cancer Center
2006-05 PHASE2
NCT00281515 COMPLETED
Epithelial Ovarian Cancer
AGO Study Group
2006-01 PHASE2
NCT00515138 TERMINATED
Lymphoma, B-Cell
University of California, San Francisco
2007-05 EARLY_PHASE1
NCT00735696 COMPLETED
Non Small Cell Lung Cancer
Eli Lilly and Company
2009-01 PHASE2
NCT01012336 COMPLETED
Chemotherapy-Induced Nausea and Vomiting; Ovarian Cancer
Samsung Medical Center
2010-05 PHASE2
NCT00482014 COMPLETED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
2007-05 PHASE1; PHASE2
NCT00550537 COMPLETED
Lung Cancer
Vanderbilt-Ingram Cancer Center
2007-10 PHASE2
NCT00352495 COMPLETED
Brain and Central Nervous System Tumors; Neurofibromatosis Type 1
Children's Oncology Group
2006-06 PHASE1
NCT00301028 COMPLETED
Head and Neck Cancer
M.D. Anderson Cancer Center
2006-04 PHASE2
NCT00821886 COMPLETED
Breast Cancer
SCRI Development Innovations, LLC
2009-02 PHASE2
NCT00231868 COMPLETED
Uterine Cancer
Montefiore Medical Center
2001-12 PHASE2
NCT00958022 TERMINATED
Small Cell Lung Cancer
Ahmad Tarhini
2009-09 PHASE1
NCT00848718 COMPLETED
Locally Advanced, Metastatic Solid Tumors
Merck Sharp & Dohme LLC
2009-03-17 PHASE1
NCT01057342 COMPLETED
Lung Cancer
Swiss Cancer Institute
2010-01 PHASE2
NCT00334321 COMPLETED
Endometrial Cancer
Washington University School of Medicine
2006-04 PHASE1
NCT00256243 COMPLETED
Breast Cancer
Rita Sanghvi, Mehta
2004-04 PHASE2
NCT00938652 COMPLETED
Breast Cancer
Sanofi
2009-07 PHASE3
NCT00687297 COMPLETED
Lung Cancer; Non Small Cell Lung Cancer
PrECOG, LLC.
2008-04 PHASE2
NCT00392886 UNKNOWN
Brain and Central Nervous System Tumors
Children's Hospital Los Angeles
2004-03 PHASE3
NCT00820872 COMPLETED
Breast Cancer
Alliance for Clinical Trials in Oncology
2009-02 PHASE2
NCT01240642 TERMINATED
Metastatic Cancer With Impaired Renal Function; Metastatic Cancer With Normal Renal Function
Novartis Pharmaceuticals
2010-01 PHASE1
NCT01100359 UNKNOWN
Endometrial Cancer
Medical University Innsbruck
2007-11 PHASE2
NCT00741988 COMPLETED
Non-Small Cell Lung Cancer
SCRI Development Innovations, LLC
2008-09 PHASE2
NCT00584909 TERMINATED
Uterine Cancer
University of Alabama at Birmingham
2006-03 PHASE2
NCT00807612 TERMINATED
Advanced Squamous Non-Small Cell Lung Cancer
NantCell, Inc.
2009-01 PHASE1; PHASE2
NCT00426582 COMPLETED
Advanced Solid Tumors
Novartis Pharmaceuticals
2006-08 PHASE1
NCT00919880 COMPLETED
Breast Cancer
Tao OUYANG
2009-07 PHASE2
NCT00520676 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
2007-10 PHASE3
NCT00687817 COMPLETED
Non-small Cell Lung Cancer
Peregrine Pharmaceuticals
2008-06 PHASE2
NCT00601718 COMPLETED
Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Waldenström Macroglobulinemia
University of Washington
2007-12 PHASE1; PHASE2
NCT00456261 COMPLETED
Lung Cancer
SCRI Development Innovations, LLC
2007-03 PHASE2
NCT00489359 COMPLETED
Ovarian Cancer; Primary Peritoneal Cancer
Eli Lilly and Company
2005-07 PHASE1; PHASE2
NCT00496028 COMPLETED
Neoplasms
AstraZeneca
2007-03 PHASE1
NCT00457119 COMPLETED
Non Small Cell Lung Cancer
Novartis Pharmaceuticals
2007-02 PHASE1
NCT00540514 COMPLETED
Non-Small Cell Lung Carcinoma
Celgene
2007-11-01 PHASE3
NCT00215930 COMPLETED
Carcinoma, Non-Small-Cell Lung
H. Lee Moffitt Cancer Center and Research Institute
2004-02 PHASE2
NCT00708812 COMPLETED
Advanced Non-small Cell Lung Cancer
Shandong Simcere-Medgenn Bio-pharmaceutical Co., Ltd
2007-07 PHASE2
NCT00101283 COMPLETED
Mesothelioma
Eastern Cooperative Oncology Group
2006-02-23 PHASE2
NCT00610714 COMPLETED
Ovarian Neoplasms; Ovarian Cancer
AstraZeneca
2008-04 PHASE2
NCT00354549 COMPLETED
Lung Cancer
Swiss Cancer Institute
2006-01 PHASE2
NCT00434252 COMPLETED
Melanoma
Genentech, Inc.
2007-02 PHASE2
NCT00508625 COMPLETED
Non-Small Cell Lung Cancer
Amgen
2006-06 PHASE2
NCT00113516 COMPLETED
Non-small Cell Lung Cancer
Pfizer
2005-09 PHASE2
NCT00316186 COMPLETED
Lung Cancer, Small Cell
GlaxoSmithKline
2005-06 PHASE2
NCT00562185 WITHDRAWN
Ovarian Cancer
University of Texas Southwestern Medical Center
2008-05 PHASE1; PHASE2
NCT00004074 COMPLETED
Advanced Adult Primary Liver Cancer; Anaplastic Thyroid Cancer; Bone Metastases; Carcinoma of the Appendix; Distal Urethral Cancer; Fallopian Tube Cancer; Gastrinoma; Glucagonoma; Inflammatory Breast Cancer; Insulinoma; Liver Metastases; Localized Unresectable Adult Primary Liver Cancer; Lung Metastases; Male Breast Cancer; Malignant Pericardial Effusion; Malignant Pleural Effusion; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Parathyroid Cancer; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Newly Diagnosed Carcinoma of Unknown Primary; Occult Non-small Cell Lung Cancer; Pancreatic Polypeptide Tumor; Primary Peritoneal Cavity Cancer; Proximal Urethral Cancer; Pulmonary Carcinoid Tumor; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adrenocortical Carcinoma; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Carcinoma of Unknown Primary; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Endometrial Carcinoma; Recurrent Esophageal Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Pancreatic Cancer; Recurrent Parathyroid Cancer; Recurrent Prostate Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Thyroid Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Vaginal Cancer; Recurrent Vulvar Cancer; Skin Metastases; Small Intestine Adenocarcinoma; Somatostatinoma; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Adrenocortical Carcinoma; Stage III Bladder Cancer; Stage III Cervical Cancer; Stage III Colon Cancer; Stage III Endometrial Carcinoma; Stage III Esophageal Cancer; Stage III Follicular Thyroid Cancer; Stage III Gastric Cancer; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Ovarian Epithelial Cancer; Stage III Pancreatic Cancer; Stage III Papillary Thyroid Cancer; Stage III Prostate Cancer; Stage III Rectal Cancer; Stage III Renal Cell Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Anal Cancer; Stage IIIA Breast Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Anal Cancer; Stage IIIB Breast Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Adrenocortical Carcinoma; Stage IV Anal Cancer; Stage IV Bladder Cancer; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Endometrial Carcinoma; Stage IV Esophageal Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Gastric Cancer; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Pancreatic Cancer; Stage IV Papillary Thyroid Cancer; Stage IV Prostate Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IVA Cervical Cancer; Stage IVA Vaginal Cancer; Stage IVB Cervical Cancer; Stage IVB Vaginal Cancer; Stage IVB Vulvar Cancer; Thyroid Gland Medullary Carcinoma; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer; Urethral Cancer Associated With Invasive Bladder Cancer; WDHA Syndrome
National Cancer Institute (NCI)
1999-08 PHASE1
NCT00511849 COMPLETED
Neoplasms
Pfizer
2005-11 PHASE1
NCT00060359 COMPLETED
Fallopian Tube Carcinoma; Malignant Ovarian Mixed Epithelial Tumor; Ovarian Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Primary Peritoneal Carcinoma; Stage III Ovarian Cancer; Stage IV Ovarian Cancer; Undifferentiated Ovarian Carcinoma
Gynecologic Oncology Group
2003-04 PHASE1
NCT00189553 COMPLETED
Ovarian Cancer; Fallopian Tube Cancer
ARCAGY/ GINECO GROUP
2005-04 PHASE3
NCT00470249 TERMINATED
Breast Cancer
University of Southampton
2006-07-15 PHASE2
NCT00498953 COMPLETED
Head and Neck Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2007-05 PHASE1; PHASE2
NCT00191451 COMPLETED
Breast Cancer
Eli Lilly and Company
2004-04 PHASE2
NCT00666692 COMPLETED
Non-small Cell Lung Cancer
Abbott
2008-04 PHASE1
NCT02004093 COMPLETED
Ovarian Cancer
Hoffmann-La Roche
2005-12 PHASE2
NCT00606125 COMPLETED
Neoplasms
Bayer
2007-05 PHASE1
NCT00369070 TERMINATED
Advanced Non-squamous NSCLC
Amgen
2007-01-31 PHASE2
NCT00561795 COMPLETED
Primary Peritoneal Carcinoma; Tumor; Epithelial Ovarian Cancer; Uterine Disease; Cervix Diseases; Neoplasms, Ovarian; Cancer
GlaxoSmithKline
2007-09 PHASE2
NCT00158379 COMPLETED
Ovarian Cancer
North Eastern German Society of Gynaecological Oncology
2003-07 PHASE2
NCT00094861 COMPLETED
Dysphagia; Non-Small Cell Lung Cancer; Lung Cancer
Swedish Orphan Biovitrum
2005-01 PHASE2
NCT00401609 COMPLETED
Small Cell Lung Cancer
National Cancer Institute, Naples
2000-11 PHASE1; PHASE2
NCT00004188 COMPLETED
Neuroblastoma
Children's Oncology Group
2001-02 PHASE3
NCT00258739 COMPLETED
Lung Neoplasms
Sanofi
2001-10 PHASE2
NCT01124435 COMPLETED
Ovarian Neoplasms
Catholic University of the Sacred Heart
2003-10 PHASE2
NCT00085501 COMPLETED
Lung Cancer
SWOG Cancer Research Network
2004-07 PHASE2
NCT00281788 COMPLETED
Esophageal Cancer
Duke University
2003-09 PHASE1
NCT00075751 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2004-01 PHASE2
NCT01172470 COMPLETED
Head and Neck Cancer
University of Chicago
2005-06 PHASE2
NCT00387374 COMPLETED
Adenosquamous Cell Lung Cancer; Drug/Agent Toxicity by Tissue/Organ; Hemoptysis; Squamous Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2006-10 PHASE2
NCT00308529 COMPLETED
Carcinoma, Small Cell Lung; Lung Cancer
SCRI Development Innovations, LLC
2006-03 PHASE2
NCT00085839 COMPLETED
Non-Small Cell Lung Cancer
OSI Pharmaceuticals
2004-02 PHASE2
NCT00014118 COMPLETED
Head and Neck Cancer
Eastern Cooperative Oncology Group
2001-06-06 PHASE2
NCT00094835 COMPLETED
Lung Cancer; Non-Small Cell Lung Cancer
Amgen
2005-01 PHASE1; PHASE2
NCT00113438 COMPLETED
Cancer; Tumor
Mateon Therapeutics
2005-03 PHASE2
NCT00061919 COMPLETED
Lung Cancer
University College, London
2003-04 PHASE3
NCT00660140 COMPLETED
Cholangiocarcinoma; Gallbladder Cancer
Washington University School of Medicine
2002-03 PHASE2
NCT00005976 COMPLETED
Brain and Central Nervous System Tumors
National Cancer Institute (NCI)
2000-05 PHASE2
NCT00255762 COMPLETED
Recurrent Melanoma; Stage IV Melanoma
National Cancer Institute (NCI)
2005-12 PHASE2
NCT00062062 COMPLETED
Lung Cancer
Alliance for Clinical Trials in Oncology
2004-10 PHASE2
NCT00161278 TERMINATED
Advanced Non-Small Cell Lung Cancer
University of Michigan Rogel Cancer Center
2004-12 PHASE2
NCT00086944 COMPLETED
Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma
National Cancer Institute (NCI)
2004-05 PHASE1; PHASE2
NCT00055835 COMPLETED
Bladder Cancer; Urethral Cancer
SWOG Cancer Research Network
2002-11 PHASE2
NCT00006235 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Gynecologic Oncology Group
PHASE1
NCT00280787 COMPLETED
Non Small Cell Lung Cancer
UNC Lineberger Comprehensive Cancer Center
2003-11 PHASE2
NCT00047255 COMPLETED
Breast Cancer
Jonsson Comprehensive Cancer Center
2002-05 PHASE3
NCT00136175 COMPLETED
Bladder Cancer
University of Michigan Rogel Cancer Center
1999-11 PHASE2
NCT00193362 COMPLETED
Lung Cancer
SCRI Development Innovations, LLC
2004-06 PHASE3
NCT00042978 COMPLETED
Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer
National Cancer Institute (NCI)
2003-04 PHASE2
NCT00007813 COMPLETED
Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Liver Cancer; Neuroblastoma; Ovarian Cancer; Sarcoma; Testicular Germ Cell Tumor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
1997-05-31 PHASE1
NCT00052338 COMPLETED
Malignant Pleural Effusion; Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2002-09 PHASE1
NCT00003864 COMPLETED
Esophageal Cancer
Eastern Cooperative Oncology Group
1999-09-03 PHASE2
NCT00005810 COMPLETED
Prostate Cancer
Alliance for Clinical Trials in Oncology
2000-03 PHASE2
NCT00002943 COMPLETED
Extragonadal Germ Cell Tumor; Ovarian Cancer; Testicular Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific
Wake Forest University Health Sciences
1993-02 PHASE2
NCT00042302 TERMINATED
Stage IIIb Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
QLT Inc.
2002-06 PHASE3
NCT00170664 COMPLETED
Ovarian Cancer
North Eastern German Society of Gynaecological Oncology
1999-01 PHASE2
NCT00017407 COMPLETED
Lung Cancer
Ionis Pharmaceuticals, Inc.
2000-10-13 PHASE3
NCT00652691 COMPLETED
Ovarian Cancer; Peritoneal Cavity Cancer
Mayo Clinic
1998-08 PHASE1
NCT00005593 COMPLETED
Leukemia; Myelodysplastic Syndromes
Case Comprehensive Cancer Center
1998-09 PHASE1
NCT00003587 COMPLETED
Lung Cancer
SWOG Cancer Research Network
1998-10 PHASE2
NCT00003378 TERMINATED
Ovarian Cancer; Primary Peritoneal Cavity Cancer
Gynecologic Oncology Group
1998-08 PHASE1
NCT00025610 COMPLETED
Neuroblastoma
European Infant Neuroblastoma Study Group - 1999
1999-07 PHASE2
NCT00003912 COMPLETED
Liver Cancer
Societe Internationale d'Oncologie Pediatrique
1998-06 PHASE3
NCT00074854 COMPLETED
Lung Neoplasms
Pfizer
2002-05 PHASE1; PHASE2
NCT00088088 COMPLETED
Stage IIIB Non-Small Cell Lung Cancer; Stage IV Non-Small Cell Lung Cancer
Synta Pharmaceuticals Corp.
2004-03 PHASE1; PHASE2
NCT00340184 COMPLETED
Cervical Cancer
Korean Gynecologic Oncology Group
2004-08 PHASE2
NCT00006049 UNKNOWN
Lung Cancer
AstraZeneca
2000-05 PHASE3
NCT00005024 UNKNOWN
Unspecified Adult Solid Tumor, Protocol Specific
Jonsson Comprehensive Cancer Center
PHASE3
NCT00003089 COMPLETED
Drug/Agent Toxicity by Tissue/Organ; Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
1997-07 PHASE2
NCT00030719 UNKNOWN
Neuroblastoma
University of Leicester
2001-12 PHASE3
NCT00004900 COMPLETED
Breast Cancer
Hackensack Meridian Health
1999-10 PHASE2
NCT00025623 COMPLETED
Neuroblastoma
European Infant Neuroblastoma Study Group - 1999
1999-07 PHASE2
NCT00417053 UNKNOWN
Neuroblastoma
Children's Cancer and Leukaemia Group
PHASE3
NCT00563160 UNKNOWN
Lung Neoplasms
Hospital Authority, Hong Kong
2005-05 PHASE2
NCT00736814 UNKNOWN
Lung Cancer
Yonsei University
2008-06 PHASE2
NCT00365755 COMPLETED
Neuroblastoma
Children's Cancer and Leukaemia Group
PHASE3
NCT00046995 UNKNOWN
Colorectal Cancer
Groupe Regional d'Etudes du Cancer Colorectal
2001-05 PHASE3
NCT00189566 COMPLETED
Ovarian Cancer; Fallopian Tube Cancer; Malignant Tumor of Peritoneum
ARCAGY/ GINECO GROUP
2004-04 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-05-15)

Check the Carboplatin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Carboplatin undergoes intracellular activation to form reactive platinum complexes that bind covalently to nucleophilic sites on DNA, inducing interstrand and intrastrand cross-links that inhibit DNA replication and transcription. This persistent DNA damage disrupts cellular repair mechanisms and triggers apoptotic cell death, underlying its clinical efficacy in inhibiting tumor growth across malignancies such as ovarian carcinoma and non-small cell lung cancer.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.