AZD5363 (Capivasertib) is a potent, ATP-competitive pan-AKT inhibitor. It affects PI3K/AKT/mTOR signaling by binding to the AKT kinase domain and suppressing downstream effectors, effectively inhibiting tumor cell proliferation and promoting apoptosis.
AZD5363 (Capivasertib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for AZD5363 (Capivasertib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.