CAS No. 928672-86-0

Batch: Purity:99.95
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Canagliflozin hemihydrate Chemical Structure
Chemical Structure
Check the Canagliflozin hemihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number 928672-86-0
Molecular Formula

C48H52F2O11S2
Molecular Weight (MW) 907.05
SMILES CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.O
InChIKey XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

Biological Activity

Canagliflozin hemihydrate is a potent sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 offor human SGLT2, demonstrating 413-fold selectivity over human SGLT1. By inhibiting SGLT2 transport in the renal proximal tubules, it suppresses the tubular reabsorption of filtered renal glucose, thereby promoting urinary glucose excretion and lowering circulating blood glucose concentrations in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (110.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nomura S, et al. J Med Chem. 2010;53(17):6355-60.

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Note: Technical data last updated: Sep 1, 2026.