CAS No. 57265-65-3
Batch:
Purity:99.82
Chemical Structure
Check the
Calmidazolium chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazol-3-ium chloride | |
|---|---|---|
| CAS Number | 57265-65-3 | |
| Molecular Formula |
C31H23Cl6N2O.Cl |
|
| Molecular Weight (MW) | 687.7 | |
| SMILES | [Cl-].ClC1=CC=C(C=C1)C([N]2C=C[N+](=C2)CC(OCC3=CC=C(Cl)C=C3Cl)C4=C(Cl)C=C(Cl)C=C4)C5=CC=C(Cl)C=C5 | |
| InChIKey | YGEIMSMISRCBFF-UHFFFAOYSA-M |
Calmidazolium chloride (R is a potent calmodulin (CaM) antagonist that inhibits CaM-stimulated rat brain phosphodiesterase and CaM-induced activation of erythrocyte Ca2+-transporting ATPase. By antagonizing CaM-dependent enzymatic activation, calmidazolium disrupts downstream calcium signaling cascades and inhibits Ca2+/CaM-regulated enzymes, including myosin light chain kinase. Consequently, this blockade impairs CaM-mediated transport processes and downstream cellular regulatory functions. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(145.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.