CAS No. 2641216-67-1

Batch: Purity:98.17
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Calderasib (MK-1084) Chemical Structure
Chemical Structure
Check the Calderasib (MK-1084) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 19-chloro-22-(2,5-dimethyl-4-prop-2-enoylpiperazin-1-yl)-13,16-difluoro-3-propan-2-yl-8,11-dioxa-1,4,23,26-tetrazapentacyclo[16.6.2.02,7.012,17.021,25]hexacosa-2(7),3,5,12,14,16,18,20,22,25-decaen-24-one
CAS Number 2641216-67-1
Molecular Formula

C32H31ClF2N6O4
Molecular Weight (MW) 637.08
SMILES FC1=C2C(OCCOC3=CC=NC(C(C)C)=C3N4C5=NC2=C(Cl)C=C5C(N6[C@@H](C)CN(C(C=C)=O)[C@H](C)C6)=NC4=O)=C(F)C=C1
InChIKey BBIVCWWQPMOKAC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Calderasib (MK-1084) is a potent and selective macrocyclic covalent inhibitor targeting mutant KRAS G12C. By covalently binding to the switch II pocket of GDP-bound KRAS G12C, it suppresses downstream RAS/RAF/MEK/ERK signaling pathway activation, thereby blocking cancer cell proliferation and suppressing tumor growth. Furthermore, calderasib exhibits robust antitumor efficacy both as a monotherapy and in combination with immune checkpoint inhibitors such as pembrolizumab in KRAS G12C-driven oncology models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (156.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.