CAS No. 63283-36-3
Batch:
Purity:98.76
Chemical Structure
Check the
Calcifediol monohydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol;hydrate | |
|---|---|---|
| CAS Number | 63283-36-3 | |
| Molecular Formula |
C27H44O2.H2O |
|
| Molecular Weight (MW) | 418.65 | |
| InChIKey | WRLFSJXJGJBFJQ-WPUCQFJDSA-N |
Calcifediol monohydrate is a vitamin D receptor (VDR) ligand and pre-hormone in the vitamin D endocrine system. As the primary circulating form of vitamin D3, calcifediol undergoes 1alpha-hydroxylation via CYP27B1 to produce active calcitriol, which engages the VDR signaling pathway. This activation regulates calcium homeostasis, bone mineral density, cell differentiation, and immune response pathways, making calcifediol essential for maintaining systemic vitamin D status. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 28 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.