CAS No. 17650-98-5

Batch: Purity:99.94
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Caerulein (Cerulein, FI-6934) Chemical Structure
Chemical Structure
Check the Caerulein (Cerulein, FI-6934) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-3-[[(2S)-5-amino-5-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]-4-[[(2S)-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid
CAS Number 17650-98-5
Molecular Formula

C58H73N13O21S2
Molecular Weight (MW) 1352.40
InChIKey YRALAIOMGQZKOW-HYAOXDFASA-N

Ordering Information

Biological Activity

Caerulein is a decapeptide that acts as a potent agonist of the cholecystokinin (CCK) receptor. Activation of CCK receptors by caerulein stimulates gastrointestinal smooth muscle contraction as well as exocrine pancreatic and biliary secretions. Furthermore, supramaximal administration of caerulein promotes dysregulated zymogen activation and acinar cell damage, making it a widely utilized agent for inducing experimental acute pancreatitis in animal models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (73.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.