CAS No. 199735-88-1
Batch:
Purity:99.82
Chemical Structure
Check the
CADD522
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(3,4-dichlorophenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid | |
|---|---|---|
| CAS Number | 199735-88-1 | |
| Molecular Formula |
C15H13Cl2NO3 |
|
| Molecular Weight (MW) | 326.17 | |
| SMILES | C1C2C=CC1C(C2C(=O)NC3=CC(=C(C=C3)Cl)Cl)C(=O)O | |
| InChIKey | YSDNWNOGHQYWPK-UHFFFAOYSA-N |
CADD522 is a potent small-molecule inhibitor of runt-related transcription factor 2 (RUNX2) DNA binding that exhibits significant anticancer activity. By blocking the direct interaction between RUNX2 and its consensus DNA binding sequences, CADD522 suppresses RUNX2-mediated transcriptional activation and downstream oncogenic signaling pathways. Consequently, inhibition of RUNX2 by CADD522 reduces cancer cell proliferation, survival, invasion, and tumor growth in experimental cancer models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
33 mg/mL
(101.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.