CAS No. 407587-33-1
Batch:
Purity:99.94
Chemical Structure
Check the
CaCCinh-A01
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-tert-butyl-2-(furan-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid | |
|---|---|---|
| CAS Number | 407587-33-1 | |
| Molecular Formula |
C18H21NO4S |
|
| Molecular Weight (MW) | 347.43 | |
| SMILES | CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3 | |
| InChIKey | ACLUEOBQFRYTQS-UHFFFAOYSA-N |
Biological Activity
CaCCinh-A01 is a small-molecule inhibitor of calcium-activated chloride channels (CaCC) with an IC50 of ~10 μM and functions as a TMEM16A blocker. By inhibiting CaCC conductance, CaCCinh-A01 prevents calcium-dependent chloride transport across apical epithelial membranes. This block of channel activity modulates transepithelial fluid secretion and downstream cellular signaling pathways, altering physiological responses in bronchial epithelial cells and vascular smooth muscle tissue. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.