CAS No. 1140909-48-3
Batch:
Purity:99.94
Chemical Structure
Check the
Cabozantinib S-malate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1140909-48-3 | |
|---|---|---|
| Molecular Formula |
C28H24FN3O5.C4H6O5 |
|
| Molecular Weight (MW) | 635.59 | |
| SMILES | COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O |
Cabozantinib S-malate is a potent multi-targeted receptor tyrosine kinase inhibitor of VEGFR2 (IC50 = and MET (IC50 =, while also inhibiting RET, KIT, AXL, and FLT3. Blockade of these signaling pathways suppresses downstream AKT and ERK activation, impairing endothelial and tumor cell migration, disrupting tumor vasculature, and inducing apoptosis in cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(157.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(157.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(157.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(157.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
127 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Cabozantinib S-malate Clinical Trials
- Cabozantinib S-malate Solubility in DMSO
- Cabozantinib S-malate Stock Solution
- Cabozantinib S-malate Storage
- Cabozantinib S-malate Stability
- Cabozantinib S-malate Molecular Weight
- Cabozantinib S-malate SMILES
- Cabozantinib S-malate Chemical Structure (2D and 3D)
- Cabozantinib S-malate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.