CAS No. 1817759-42-4

Batch: Purity:98.72
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Cabozantinib hydrochloride Chemical Structure
Chemical Structure
Check the Cabozantinib hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;hydrochloride
CAS Number 1817759-42-4
Molecular Formula

C28H24FN3O5.ClH
Molecular Weight (MW) 537.97
InChIKey LCNVAOXPKXBXEH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Cabozantinib hydrochloride is a multi-kinase inhibitor targeting VEGFR2, c-MET, KIT, RET, AXL, FLT3 (IC50 1, and Tie2. By disrupting receptor tyrosine kinase phosphorylation, it blocks downstream RAS/MAPK and PI3K/AKT signaling cascades. These actions lead to suppressed endothelial cell migration, attenuated tumor cell proliferation, and inhibited tumor angiogenesis and invasive metastasis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (37.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.