CAS No. 138777-25-0
Chemical Structure
Check the
C12FDG
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[3-oxo-3',6'-bis[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]spiro[2-benzofuran-1,9'-xanthene]-5-yl]dodecanamide | |
|---|---|---|
| CAS Number | 138777-25-0 | |
| Molecular Formula |
C44H55NO16 |
|
| Molecular Weight (MW) | 853.90 | |
| SMILES | CCCCCCCCCCCC(NC1=CC2=C(C3(C4=C(OC5=C3C=CC(O[C@H]6[C@@H]([C@H]([C@H]([C@@H](CO)O6)O)O)O)=C5)C=C(O[C@H]7[C@@H]([C@H]([C@H]([C@@H](CO)O7)O)O)O)C=C4)OC2=O)C=C1)=O | |
| InChIKey | SLIWIQKBDGZFQR-PIVCGYGYSA-N |
Biological Activity
C12FDG is a lipophilic fluorogenic substrate used for detecting β-galactosidase activity in cells. Upon cleavage by endogenous β-galactosidase, C12FDG yields a membrane-impermeant green fluorescent product that accumulates intracellularly. This functional substrate enables sensitive fluorometric and flow cytometric quantification of lysosomal senescence-associated β-galactosidase activity, serving as a reliable biomarker to identify cellular senescence during replicative aging and stress-induced growth arrest. [1][2]
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Reference
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Note: Technical data last updated: Sep 1, 2026.