CAS No. 1104546-89-5
Batch:
Purity:98.67
Chemical Structure
Check the
BYK204165
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4Z)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione | |
|---|---|---|
| CAS Number | 1104546-89-5 | |
| Molecular Formula |
C15H12N2O2 |
|
| Molecular Weight (MW) | 252.27 | |
| SMILES | CN1C=CC=C1C=C2C3=CC=CC=C3C(=O)NC2=O | |
| InChIKey | BTYSIDSTHDDAJW-LCYFTJDESA-N |
BYK204165 is a potent and selective poly(ADP-ribose) polymerase inhibitor that targets human PARP-1 and murine PARP-2. Inhibition of PARP-1 activity blocks poly(ADP-ribose) chain synthesis and prevents cellular NAD+ and ATP depletion following genomic DNA damage. Consequently, this compound suppresses energetic failure, attenuates necrotic cell death, and modulates downstream pro-inflammatory response pathways involved in oxidative cellular injury. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(198.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.