CAS No. 101155-02-6
Batch:
Purity:99.87
Chemical Structure
Check the
BW-A78U
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine | |
|---|---|---|
| CAS Number | 101155-02-6 | |
| Molecular Formula |
C13H12FN5
|
|
| Molecular Weight (MW) | 257.27 | |
| SMILES | CNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F | |
| InChIKey | MZABAGHILOTTOD-UHFFFAOYSA-N |
Biological Activity
BW-A78U is an adenine derivative that acts as a phosphodiesterase (PDE) inhibitor with potent anticonvulsant activity. By inhibiting cyclic nucleotide phosphodiesterase enzymes, it prevents the degradation of second messengers, leading to elevated intracellular levels of cAMP and cGMP. This alteration in cyclic nucleotide signaling modulates downstream neuronal kinase cascades, resulting in reduced cellular hyperexcitability and suppression of seizure activity in preclinical neural models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(198.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 26 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.