CAS No. 376640-41-4

Batch: Purity:99.94
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BVT 2733 Chemical Structure
Chemical Structure
Check the BVT 2733 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide
CAS Number 376640-41-4
Molecular Formula

C17H21ClN4O3S2
Molecular Weight (MW) 428.96
SMILES CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=CS2)CC(=O)N3CCN(CC3)C
InChIKey YDPRNGAPPNPYQQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

BVT 2733 is a non-steroidal, isoform-selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). By blocking 11β-HSD1 activity, it prevents the local conversion of inactive glucocorticoids to active cortisol, thereby downregulating glucocorticoid receptor signaling. This inhibition modulates hepatic metabolic pathways, suppressing gluconeogenic gene expression and enhancing insulin sensitivity to decrease elevated blood glucose levels in metabolic disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (200.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.