CAS No. 1110767-45-7
Batch:
Purity:98.21
Chemical Structure
Check the
Butyzamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-3-[2,6-dichloro-4-[[4-[3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid | |
|---|---|---|
| CAS Number | 1110767-45-7 | |
| Molecular Formula |
C29H32Cl2N2O5S |
|
| Molecular Weight (MW) | 591.55 | |
| InChIKey | BBEZGQPYGPBSLA-FOWTUZBSSA-N |
Biological Activity
Butyzamide is a non-peptidyl thrombopoietin receptor agonist that specifically activates Mpl. Upon binding, it augments the phosphorylation levels of downstream signaling mediators including JAK2, STAT3, STAT, and MAPK. Activation of these cascades promotes progenitor cell survival, megakaryocyte differentiation, and megakaryocyte polyploidization, ultimately driving functional platelet production and offering potential therapeutic utility for the management of thrombocytopenia. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(169.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.