CAS No. 94-25-7
Batch:
Purity:99.92
Chemical Structure
Check the
Butamben
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | butyl 4-aminobenzoate | |
|---|---|---|
| CAS Number | 94-25-7 | |
| Molecular Formula |
C11H15NO2 |
|
| Molecular Weight (MW) | 193.24 | |
| SMILES | CCCCOC(=O)C1=CC=C(C=C1)N | |
| InChIKey | IUWVALYLNVXWKX-UHFFFAOYSA-N |
Biological Activity
Butamben is an ester-type local anesthetic that functions as a blocker of voltage-gated sodium channels. By reversibly binding to voltage-gated sodium channels in neuronal membranes, it prevents influx of sodium ions and inhibits the initiation and propagation of action potentials. This blockade interrupts nerve impulse transmission along sensory nerve fibers, leading to prolonged attenuation of nociceptive signal propagation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(196.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 38 mg/mL |
| Ethanol | 38 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.