CAS No. 107668-79-1

Batch: Purity:99.99
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Bulleyaconi cine A Chemical Structure
Chemical Structure
Check the Bulleyaconi cine A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1S,2R,3R,4R,5R,6S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-11-ethyl-5-hydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] 4-methoxybenzoate
CAS Number 107668-79-1
Molecular Formula

C35H49NO9
Molecular Weight (MW) 627.76
SMILES CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6(CC4C5C6C(=O)C7=CC=C(C=C7)OC)O)OC)OC(=O)C)OC)OC)COC
InChIKey GAZDXIGXYWVWQX-NWDFBOQYSA-N

Ordering Information

Biological Activity

Bulleyaconi cine A (Bulleyaconitine A) is an aconitine-like alkaloid that acts as a use-dependent blocker of Nav1.7 and Nav1.8 voltage-gated sodium currents. By inhibiting sodium influx in primary sensory dorsal root ganglion neurons, it suppresses action potential firing and neuronal excitability. Downstream, this targeted inhibition disrupts nociceptive signal transmission and effectively reduces pain signaling in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (11.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.