CAS No. 938448-87-4
Batch:
Purity:98.83
Chemical Structure
Check the
Bucladesine calcium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 938448-87-4 | |
|---|---|---|
| Molecular Formula |
C18H24N5O8P.1/2Ca |
|
| Molecular Weight (MW) | 978.8 |
Biological Activity
Bucladesine calcium (Dibutyryl-cAMP calcium salt) is a cell-permeable analog of cyclic AMP (cAMP) that functions as a potent protein kinase A (PKA) activator. By mimicking endogenous cAMP, it stimulates downstream cAMP/PKA signaling cascades and exerts inhibitory activity against phosphodiesterase (PDE). Activation of PKA by this compound modulates cellular pathways involved in cardiac function, inflammation, and tissue repair processes such as wound healing. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(102.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | 25 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.