CAS No. 18331-34-5
Batch:
Purity:99.98
Chemical Structure
Check the
BTR-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 18331-34-5 | |
|---|---|---|
| Molecular Formula |
C12H11NOS2 |
|
| Molecular Weight (MW) | 249.35 | |
| SMILES | CCN1C(=O)C(=CC2=CC=CC=C2)SC1=S |
BTR-1 is a small-molecule cytotoxic agent that disrupts cell growth and survival in leukemia. Treatment with BTR-1 induces cytotoxicity in CEM leukemia cells in a time- and concentration-dependent manner. Mechanistically, BTR-1 impairs DNA replication by inducing cell cycle arrest at the S phase, which subsequently triggers apoptotic cascades to promote programmed cell death and suppress leukemic cell proliferation. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(52.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.