CAS No. 86030-08-2
Batch:
Purity:99.76
Chemical Structure
Check the
BTB-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(benzenesulfonyl)-4-chloro-2-nitrobenzene | |
|---|---|---|
| CAS Number | 86030-08-2 | |
| Molecular Formula |
C12H8ClNO4S |
|
| Molecular Weight (MW) | 297.71 | |
| SMILES | C1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2)Cl)[N+](=O)[O-] | |
| InChIKey | VZDUQPHKUBZMLW-UHFFFAOYSA-N |
BTB-1 is a selective and reversible inhibitor of the mitotic motor protein Kif18A, demonstrating an IC50 offor inhibition of its ATPase activity. By targeting Kif18A, BTB-1 interferes with microtubule dynamics during mitosis, impairing chromosome alignment at the metaphase plate and increasing mitotic spindle length. Consequently, this inhibition triggers spindle assembly checkpoint activation, leading to mitotic arrest and inhibition of cell proliferation.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(201.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.