CAS No. 14907-98-3

Batch: Purity:99.96
Check CoA
Brusatol Chemical Structure
Chemical Structure
Check the Brusatol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-10,15,16-trihydroxy-9,13-dimethyl-3-(3-methylbut-2-enoyloxy)-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate
CAS Number 14907-98-3
Molecular Formula

C26H32O11
Molecular Weight (MW) 520.53
SMILES CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)C=C(C)C)(OC5)C(=O)OC)O)O)C)O
InChIKey ZZZYHIMVKOHVIH-VILODJCFSA-N

Ordering Information

Biological Activity

Brusatol is a quassinoid compound isolated from Brucea javanica that acts as a potent NRF2 pathway inhibitor. It reduces NRF2 protein accumulation by accelerating its degradation, thereby suppressing the expression of NRF2-driven antioxidant response genes. Consequently, Brusatol disrupts redox homeostasis, elevates intracellular reactive oxygen species, and sensitizes diverse cancer cell lines to chemotherapeutic agents.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.