CAS No. 60583-39-3

Batch: Purity:98
Check CoA
Brucine sulfate heptahydrate Chemical Structure
Chemical Structure
Check the Brucine sulfate heptahydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name bis((4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one);sulfuric acid;heptahydrate
CAS Number 60583-39-3
Molecular Formula

C46H68N4O19S
Molecular Weight (MW) 1013.11
SMILES COC1=C(C=C2C(=C1)C34CCN5C3CC6C7C4N2C(=O)CC7OCC=C6C5)OC.COC1=C(C=C2C(=C1)C34CCN5C3CC6C7C4N2C(=O)CC7OCC=C6C5)OC.O.O.O.O.O.O.O.OS(=O)(=O)O
InChIKey PPJIVFYMRNHHTJ-JYGVWXPPSA-N

Ordering Information

Biological Activity

Brucine sulfate heptahydrate is an alkaloid derivative that functions as an antagonist of glycine receptors. By inhibiting glycine receptor-mediated chloride influx, it paralyzes inhibitory neurotransmission in the central nervous system. This blockade disrupts inhibitory synaptic signaling, leading to increased neuronal excitability and altered spinal cord signaling pathways. Consequently, brucine serves as a key pharmacological tool for investigating glycinergic inhibition and neuronal circuitry. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (98.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.