CAS No. 120638-55-3

Batch: Purity:99.92
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Bromfenac sodium hydrate Chemical Structure
Chemical Structure
Check the Bromfenac sodium hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name disodium;bis(2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate);trihydrate
CAS Number 120638-55-3
Molecular Formula

C30H28Br2N2Na2O9
Molecular Weight (MW) 766.34
SMILES O.O.O.[Na+].[Na+].NC1=C(CC([O-])=O)C=CC=C1C(=O)C2=CC=C(Br)C=C2.NC3=C(CC([O-])=O)C=CC=C3C(=O)C4=CC=C(Br)C=C4
InChIKey PPOSVVJOVKVBPW-UHFFFAOYSA-L

Ordering Information

Biological Activity

Bromfenac sodium hydrate is a potent, orally active, brominated nonsteroidal anti-inflammatory drug (NSAID) that functions as an inhibitor of cyclooxygenase, targeting COX-1 and COX-2. By inhibiting COX-mediated arachidonic acid metabolism, the compound suppresses downstream prostaglandin biosynthesis, blunting NF-kB signaling activation and pro-inflammatory cytokine release to attenuate localized pain and tissue inflammation phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (130.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.