CAS No. 193611-72-2
Batch:
Purity:99.92
Chemical Structure
Check the
BRL-15572 Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 193611-72-2 | |
|---|---|---|
| Molecular Formula |
C25H27ClN2O.2HCl |
|
| Molecular Weight (MW) | 479.87 | |
| SMILES | C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl |
BRL-15572 Dihydrochloride is a selective serotonin 5-HT1D receptor antagonist (pKi 7.9) that displays 60-fold selectivity over the 5-HT1B receptor, as well as affinity for 5-HT1A and 5-HT2B receptors. By modulating serotonin receptor signaling, it regulates neurotransmitter release and inhibits sumatriptan-mediated modulation of GABAergic synaptic transmission in neural pathways.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- BRL-15572 Dihydrochloride Solubility in DMSO
- BRL-15572 Dihydrochloride Stock Solution
- BRL-15572 Dihydrochloride Storage
- BRL-15572 Dihydrochloride Stability
- BRL-15572 Dihydrochloride Molecular Weight
- BRL-15572 Dihydrochloride SMILES
- BRL-15572 Dihydrochloride Chemical Structure (2D and 3D)
- BRL-15572 Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.