CAS No. 69304-47-8

Batch: Purity:99.29
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Brivudine (BVDU) Chemical Structure
Chemical Structure
Check the Brivudine (BVDU) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 69304-47-8
Molecular Formula

C11H13BrN2O5
Molecular Weight (MW) 333.14
SMILES C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O

Biological Activity

Brivudine (BVDU) is a nucleoside analog and antiviral uridine derivative that selectively targets viral DNA polymerase. Following intracellular phosphorylation, BVDU is incorporated directly into viral DNA to inhibit viral DNA polymerase activity, effectively blocking viral replication. Beyond its primary antiviral mechanism, BVDU exhibits pro-apoptotic and chemosensitizing properties in preclinical cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 67 mg/mL (201.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 17 mg/mL
Water 6 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Proc. Natl. Acad. Sci. U.S.A. 1979;76(12):6775-6787.

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Note: Technical data last updated: Sep 1, 2026.