CAS No. 503105-88-2
Batch:
Purity:99.50
Chemical Structure
Check the
BRITE338733
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-(5-ethylfuran-2-yl)-6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-pyridinyl]-4-methylphenol | |
|---|---|---|
| CAS Number | 503105-88-2 | |
| Molecular Formula |
C27H35N3O2 |
|
| Molecular Weight (MW) | 433.59 | |
| SMILES | CCC1=CC=C(O1)C2=CC(=NC(=C2)NC3CC(NC(C3)(C)C)(C)C)C4=C(C=CC(=C4)C)O | |
| InChIKey | PKYYVDCUXJXUPN-UHFFFAOYSA-N |
BRITE-338733 is a potent inhibitor of RecA, a bacterial DNA-dependent ATPase. By directly targeting RecA, this compound inhibits RecA-mediated ATP hydrolysis and single-stranded DNA binding, thereby disrupting bacterial homologous recombination and blocking the activation of the SOS response pathway. Downstream, RecA inhibition suppresses bacterial DNA repair mechanisms, sensitizing bacterial cells to DNA damage and impairing hypermutation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(200.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.