CAS No. 6104-58-1

Brilliant Blue G Chemical Structure
Chemical Structure
Check the Brilliant Blue G product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6104-58-1
Molecular Formula
C47H48N3NaO7S2
Molecular Weight (MW) 854.02
SMILES [Na+].CCOC1=CC=C(NC2=CC=C(C=C2)\C(C3=CC=C(C=C3C)N(CC)CC4=CC=CC(=C4)[S]([O-])(=O)=O)=C/5C=CC(/C=C5C)=[N+](/CC)CC6=CC=CC(=C6)[S]([O-])(=O)=O)C=C1

Biological Activity

Brilliant Blue G is a protein dye and potent non-competitive antagonist of the P2X7 receptor, inhibiting rat P2X7 (IC50 10.1 nM) and human P2X7 (IC50 265 nM). By blocking P2X7 receptor activation, it prevents ATP-induced cell pore formation, pro-inflammatory cytokine release, and cellular toxicity. This targeted inhibition suppresses neuroinflammatory signaling and mitigates experimental neurodegenerative and autoimmune pathologies in preclinical animal models.

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Note: Technical data last updated: Sep 1, 2026.