CAS No. 1197953-54-0
Batch:
Purity:99.91
Chemical Structure
Check the
Brigatinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 1197953-54-0 | |
| Molecular Formula |
C29H39ClN7O2P |
|
| Molecular Weight (MW) | 584.09 | |
| SMILES | CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC | |
| InChIKey | AILRADAXUVEEIR-UHFFFAOYSA-N |
Biological Activity
Brigatinib is a potent kinase inhibitor targeting ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM), while also inhibiting IGF-1R, FLT3, and mutant variants of FLT3 and EGFR with lower potency. By blocking ALK and ROS1 kinase activation, it suppresses downstream STAT3, AKT, and ERK signaling pathways. This inhibition reduces oncogenic signal transduction and inhibits cellular proliferation and survival in driver-dependent cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 2 mg/mL |
| DMSO |
1 mg/mL
(1.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 5 mg/mL |
| DMSO |
1 mg/mL
(1.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
3 mg/mL
(5.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| Ethanol | 5 mg/mL |
| DMSO |
2 mg/mL
(3.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.