CAS No. 16503-32-5
Batch:
Purity:99.89
Chemical Structure
Check the
Brevilin A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate | |
|---|---|---|
| CAS Number | 16503-32-5 | |
| Molecular Formula |
C20H26O5 |
|
| Molecular Weight (MW) | 346.42 | |
| InChIKey | KUPPZVXLWANEJJ-UXPPPGSFSA-N |
Brevilin A is a natural sesquiterpene lactone that selectively inhibits STAT3 and attenuates Janus kinase (JAK) activity by blocking the JH1 tyrosine kinase domain. It inactivates the PI3K/AKT/mTOR signaling pathway and triggers mitochondrial dysfunction, thereby inducing apoptosis and autophagy in CT26 colon adenocarcinoma cells. These mechanisms together suppress downstream cell survival and proliferation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.