CAS No. 1802148-05-5
Batch:
Purity:99.67
Chemical Structure
Check the
Brensocatib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide | |
|---|---|---|
| CAS Number | 1802148-05-5 | |
| Molecular Formula |
C23H24N4O4 |
|
| Molecular Weight (MW) | 420.46 | |
| InChIKey | AEXFXNFMSAAELR-RXVVDRJESA-N |
Brensocatib is an oral, selective, and reversible inhibitor of dipeptidyl peptidase-1 (DPP-1). By targeting DPP-1 during neutrophil maturation, it prevents the activation of key neutrophil serine proteases, including neutrophil elastase, proteinase, and cathepsin G. This suppression of serine protease activity reduces inflammatory signal processing and attenuates tissue damage driven by neutrophilic inflammation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.