CAS No. 1374601-41-8
Batch:
Purity:99.52
Chemical Structure
Check the
BRD9539
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylic acid | |
|---|---|---|
| CAS Number | 1374601-41-8 | |
| Molecular Formula |
C24H21N3O3 |
|
| Molecular Weight (MW) | 399.44 | |
| SMILES | OC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4 | |
| InChIKey | WPXMEOBILYVKBC-UHFFFAOYSA-N |
BRD9539 is a synthetic small-molecule histone methyltransferase inhibitor that targets G9a and attenuates PRC2 activity. By suppressing G9a- and PRC2-mediated histone methylation, BRD9539 modulates epigenetic gene regulation and alters chromatin architecture in target cells. Consequently, inhibition of these histone methyltransferases impairs cancer cell proliferation and alters transcriptional programs downstream of epigenetic regulatory pathways. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.