CAS No. 1440209-96-0
| IUPAC Name | 3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide | |
|---|---|---|
| CAS Number | 1440209-96-0 | |
| Molecular Formula |
C16H16N2O3 |
|
| Molecular Weight (MW) | 284.31 | |
| SMILES | C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO | |
| InChIKey | FIHKWEQJEDRIFS-UHFFFAOYSA-N |
BRD73954 is a potent histone deacetylase (HDAC) inhibitor that selectively targets HDAC6 and HDAC8. By suppressing HDAC enzymatic activity, BRD73954 promotes hyperacetylation of histone and non-histone substrates, such as alpha-tubulin, thereby disrupting intracellular transport, cytoskeletal dynamics, and protein homeostasis. Inhibition of these signaling pathways alters chromatin structure and suppresses cell proliferation while inducing apoptosis in cellular models of cancer. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(196.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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