CAS No. 1374601-40-7
Batch:
Purity:99.98
Chemical Structure
Check the
BRD4770
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate | |
|---|---|---|
| CAS Number | 1374601-40-7 | |
| Molecular Formula |
C25H23N3O3 |
|
| Molecular Weight (MW) | 413.47 | |
| SMILES | COC(=O)C1=CC2=C(C=C1)N(C(=N2)NC(=O)C3=CC=CC=C3)CCCC4=CC=CC=C4 | |
| InChIKey | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
BRD4770 is a novel small-molecule inhibitor targeting histone methyltransferase G9a with an IC50 of 6.3 μM. By inhibiting G9a catalytic activity, BRD4770 selectively depletes cellular di-methylated histone H3 lysine 9 (H3K9me2) levels without affecting other methylation states. This blockade of chromatin modification pathways induces downstream cellular senescence, reduces colony formation, and suppresses proliferation in human pancreatic cancer cells.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(48.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(106.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.