CAS No. 2056261-41-5
Batch:
Purity:99.96
Chemical Structure
Check the
BRD0705
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[5,4-b]quinolin-5-one | |
|---|---|---|
| CAS Number | 2056261-41-5 | |
| Molecular Formula |
C20H23N3O
|
|
| Molecular Weight (MW) | 321.42 | |
| SMILES | CCC1(C2=CC=CC=C2)C3=CNNC3=NC4=C1C(=O)CC(C)(C)C4 | |
| InChIKey | NCKLQXXBRWCYMA-FQEVSTJZSA-N |
BRD0705 is a potent, paralog-selective, and orally active inhibitor of GSK3α and GSK3β. Target inhibition impairs leukemic progenitor cell proliferation and selectively induces myeloid differentiation in acute myeloid leukemia cells, promoting lineage maturation without triggering β-catenin accumulation or severe toxicity typically associated with dual GSK3α and GSK3β kinase inhibition. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.