CAS No. 2329719-65-3

Batch: Purity:99.34
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BRD-810 Chemical Structure BRD-810 Chemical Structure
Chemical Structure
Check the BRD-810 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (7R)-19-chloro-3-ethyl-15-[3-(6-fluoronaphthalen-1-yl)oxypropyl]-4-methyl-7-(2-morpholin-4-ylethyl)-8-oxa-4,5,13-triazatetracyclo[11.6.1.02,6.016,20]icosa-1(19),2,5,14,16(20),17-hexaene-14-carboxylic acid
CAS Number 2329719-65-3
Molecular Formula

C39H44ClFN4O5
Molecular Weight (MW) 703.24
InChIKey RQXSLNDYCDRXAC-MGBGTMOVSA-N

Ordering Information

Biological Activity

BRD-810 is a potent and highly selective inhibitor of myeloid cell leukemia 1 (MCL1). By binding to the BH3-binding pocket of MCL1, BRD-810 disrupts its interaction with pro-apoptotic proteins and blocks their sequestration. This disruption restores pro-apoptotic signalling and rapidly triggers downstream caspase activation in MCL1-dependent cancer cells, leading to anti-tumor effects across hematologic malignancies and solid tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (142.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.