CAS No. 474-07-7
Batch:
Purity:99.72
Chemical Structure
Check the
Brazilin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 474-07-7 | |
|---|---|---|
| Molecular Formula |
C16H14O5 |
|
| Molecular Weight (MW) | 286.28 | |
| SMILES | C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4)O)O)O)O |
Biological Activity
Brazilin is a natural bioactive compound that exhibits anti-inflammatory, neuroprotective, and antioxidant activities. It inhibits lipopolysaccharide-induced IκB kinase activity and nuclear factor-kappaB (NF-kB) activation, leading to downstream suppression of inducible nitric oxide synthase expression and inflammatory mediator production in macrophage models. Through these targeted pathway modulations, brazilin attenuates inflammatory responses and exerts broad cytoprotective phenotypes in cellular assays. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | 28 mg/mL |
| DMSO |
57 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.