CAS No. 1912445-55-6

Batch: Purity:99.87
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Branebrutinib (BMS-986195) Chemical Structure
Chemical Structure
Check the Branebrutinib (BMS-986195) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
CAS Number 1912445-55-6
Molecular Formula

C20H23FN4O2
Molecular Weight (MW) 370.42
SMILES CC#CC(=O)NC1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F
InChIKey VJPPLCNBDLZIFG-ZDUSSCGKSA-N

Ordering Information

Biological Activity

Branebrutinib (BMS-986195) is a potent Bruton's tyrosine kinase inhibitor that inhibits BTK (IC50 =, TEC (IC50 =, BMX (IC50 =, and TXK (IC50 =. By selectively targeting BTK, it disrupts B-cell receptor and Fc receptor signaling pathways, impairing downstream kinase activation. This blockade suppresses B-cell proliferation and reduces pro-inflammatory cytokine production, leading to inhibited autoantibody responses and attenuated immune cell-mediated inflammatory processes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 38 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.