CAS No. 1562338-42-4

Batch: Purity:99.85
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Branaplam (LMI070) Chemical Structure
Chemical Structure
Check the Branaplam (LMI070) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(1H-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol
CAS Number 1562338-42-4
Molecular Formula

C22H27N5O2
Molecular Weight (MW) 393.48
SMILES CC1(CC(CC(N1)(C)C)OC2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C
InChIKey STWTUEAWRAIWJG-UHFFFAOYSA-N

Biological Activity

Branaplam (LMI070) is a selective small-molecule survival motor neuron-2 (SMN2) splicing modulator with an EC50 of. It promotes the inclusion of exon 7 during SMN2 pre-mRNA splicing, leading to increased production of full-length functional SMN protein. This elevation of SMN protein suppresses motor neuron degeneration and improves phenotypic survival in preclinical models of spinal muscular atrophy.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 3 mg/mL (7.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.