CAS No. 2290527-07-8

Batch: Purity:99.23
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Bractoppin Chemical Structure
Chemical Structure
Check the Bractoppin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2290527-07-8
Molecular Formula

C25H23FN4O
Molecular Weight (MW) 414.48
SMILES FC1=CC=CC=C1CN2CCN(CC2)C(=O)C3=CC=C4N=C([NH]C4=C3)C5=CC=CC=C5

Biological Activity

Bractoppin is a potent inhibitor of phosphopeptide recognition by the human BRCA1 tandem BRCT domain. By disrupting target phosphopeptide binding to the tandem BRCT module, it interferes with critical protein interactions within the DNA damage response pathway. Consequently, inhibition of this recognition domain impairs downstream double-strand break repair cascades and checkpoint signaling mechanisms. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (200.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 83 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Manke IA, et al. Science. 2003;302(5645):636-9.

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Note: Technical data last updated: Sep 1, 2026.