CAS No. 338747-41-4
Batch:
Purity:99.18
Chemical Structure
Check the
BQCA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(4-methoxyphenyl)methyl]-4-oxoquinoline-3-carboxylic acid | |
|---|---|---|
| CAS Number | 338747-41-4 | |
| Molecular Formula |
C18H15NO4 |
|
| Molecular Weight (MW) | 309.32 | |
| SMILES | COC1=CC=C(C=C1)CN2C=C(C(=O)C3=CC=CC=C32)C(=O)O | |
| InChIKey | BZBBTGCKPRSPGF-UHFFFAOYSA-N |
BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). By potentiating agonist-mediated M1 mAChR activation, BQCA enhances downstream cholinergic signaling, potentiates NMDA receptor-mediated synaptic responses, and promotes long-term potentiation in hippocampal circuits. These target-specific cellular mechanisms contribute to enhanced cognitive performance and restored synaptic plasticity in preclinical rodent models. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(42.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.