CAS No. 314045-39-1
Batch:
Purity:97
Chemical Structure
Check the
BPTES
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-phenyl-N-[5-[2-[2-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]ethylsulfanyl]ethyl]-1,3,4-thiadiazol-2-yl]acetamide | |
|---|---|---|
| CAS Number | 314045-39-1 | |
| Molecular Formula |
C24H24N6O2S3 |
|
| Molecular Weight (MW) | 524.68 | |
| SMILES | C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4 | |
| InChIKey | MDJIPXYRSZHCFS-UHFFFAOYSA-N |
BPTES is a potent and selective inhibitor of kidney-type glutaminase (GLS1/KGA). By selectively inhibiting GLS1 activity, BPTES blocks the conversion of glutamine to glutamate, disrupting tricarboxylic acid (TCA) cycle flux and downstream mitochondrial oxidative phosphorylation. This inhibition depletes intracellular ATP levels, suppresses cellular bioenergetics, and impairs glutamine-dependent cancer cell proliferation and survival. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(95.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(95.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
25 mg/mL
(47.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- BPTES Mechanism of Action: GLS1 Inhibition in Cancer Cell Research
- BPTES Working Concentration | Cell Culture | Treatment
- BPTES Solubility in DMSO
- BPTES Stock Solution
- BPTES Storage
- BPTES Stability
- BPTES Combination Database
- BPTES Molecular Weight
- BPTES SMILES
- BPTES Chemical Structure (2D and 3D)
- BPTES IC50 for Cell-based and Cell-free Assays
- BPTES Sigma (SML0601)? Try a better option.
- BPTES MedChemExpress (HY-12683)? Try a better option.
- BPTES Cayman (19284)? Try a better option.
- BPTES Tocris (5301)? Try a better option.
- BPTES APExBIO (B6008)? Try a better option.
- BPTES SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.