Borneol

For research use only.

Catalog No.S3605

Borneol Chemical Structure

Molecular Weight(MW): 154.25

Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.

Size Price Stock Quantity  
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective TRP Channel Inhibitors

Biological Activity

Description Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.
Targets
TRPM8 [2]
(cell-based assay)
65 μM(EC50)
In vitro

Borneol activates TRPM8 channel in a temperature- and dose-dependent manner. Borneol at micromolar concentrations do not affect the viability of human corneal epithelial cells. Borneol has been found to activate TRPV3 channel, which belongs to the heat-activated vanilloid family of TRP channels[1]. Borneol can potentiate (EC50 = 248 μM) or directly activate (> 1.5 mM) the GABAA receptor, activate the TRPV3 channel (EC50 = 3.45 ± 0.13 mM), and inhibit the TRPA1 channel (IC50 = 0.5 ± 0.3 or 0.20 ± 0.06 mM)[2].

In vivo Borneol is widely used in ophthalmic preparations and classic formulas of Traditional Chinese Medicine to treat various diseases including oculopathies, oral ulcers, sore throat, skin diseases and mild neurological disorders, and found to produce anti-inflammatory, anti-bacterial and analgesic effects. Borneol can increase tear secretion via activating the cold-sensing TRPM8 channel in the cornea[1]. borneol may facilitate the delivery of other effective components and enhance their effects in combinatorial herbal formulas. Thus, borneol is also orally administered as an adjuvant component for the treatment of a variety of diseases. topical borneol provides analgesic effects in three different mouse models of pain[2].

Protocol

Cell Research:

[1]

- Collapse
  • Cell lines: HEK293 and HCE cells
  • Concentrations: --
  • Incubation Time: 24 h
  • Method:

    The viability of HEK293 and HCE cells is measured with WST-1 reagent. Briefly, cells are seeded in 96-well plates to reach a confluency of 50–60%. Borneol or menthol is added into the cell culture medium and incubated for 24 h. WST-1 (10 μl) is then added into each well and incubated for 2 h. Absorbance at 450 nm (A450) and 690 nm (A690) is measured in a plate reader. The subtracted value (A450-A690) is used to evaluate viability of the cells.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (194.48 mM)
Ethanol 30 mg/mL (194.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 154.25
Formula

C10H18O

CAS No. 507-70-0
Storage powder
in solvent
Synonyms N/A
Smiles CC1(C)C2CCC1(C)C(O)C2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Borneol | Borneol supplier | purchase Borneol | Borneol cost | Borneol manufacturer | order Borneol | Borneol distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID