CAS No. 476-70-0
Batch:
Purity:99.83
Chemical Structure
Check the
Boldine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 476-70-0 | |
|---|---|---|
| Molecular Formula |
C19H21NO4 |
|
| Molecular Weight (MW) | 327.37 | |
| SMILES | CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O |
Biological Activity
Boldine, a natural aporphine alkaloid isolated from Peumus boldus, acts as an alpha-adrenergic receptor antagonist and potent free-radical scavenger. By neutralizing reactive oxygen species and inhibiting lipid peroxidation, boldine exerts cytoprotective and hepatoprotective actions in vascular and hepatic tissues. Furthermore, it attenuates inflammatory mediator release and suppresses fever in vivo, mediating broad anti-inflammatory and antipyretic biological activities. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
65 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.