CAS No. 27219-07-4

Batch: Purity:99.54
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5-Boc-amino-pentanoic acid Chemical Structure
Chemical Structure
Check the 5-Boc-amino-pentanoic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 27219-07-4
Molecular Formula

C10H19NO4
Molecular Weight (MW) 217.26
SMILES CC(C)(C)OC(=O)NCCCCC(=O)O

Ordering Information

Biological Activity

5-Boc-amino-pentanoic acid is an alkyl-based PROTAC linker utilized in the chemical synthesis of targeted protein degraders. Incorporating functionalized alkyl linkers enables the conjugation of target-protein ligands to E3 ubiquitin ligase recruiters. Chimeric degraders utilizing such linkers facilitate ubiquitin-proteasome system-mediated degradation of the Polycomb repressive complex 2 core subunits EED, EZH2, and SUZ12, suppressing downstream oncogenic signaling and epigenetic gene repression pathways.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (197.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 43 mg/mL
Ethanol 43 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.