CAS No. 2280037-51-4
Batch:
Purity:99.87
Chemical Structure
Check the
Bobcat339
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-amino-5-chloro-1-(3-phenylphenyl)pyrimidin-2-one | |
|---|---|---|
| CAS Number | 2280037-51-4 | |
| Molecular Formula |
C16H12ClN3O |
|
| Molecular Weight (MW) | 297.74 | |
| InChIKey | QMGYGOOYCNTEQO-UHFFFAOYSA-N |
Bobcat339 is a cytosine-based inhibitor of TET1 (IC50 = and TET2 (IC50 =. By inhibiting TET-mediated oxidation of 5-methylcytosine, it reduces genomic 5-hydroxymethylcytosine (5hmC) levels in hippocampal neurons. This loss of 5hmC alters DNA methylation dynamics and downstream gene transcription, serving as a valuable chemical tool for epigenetic regulation studies. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(201.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.