CAS No. 2408648-20-2
| IUPAC Name | 3-(4-methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine | |
|---|---|---|
| CAS Number | 2408648-20-2 | |
| Molecular Formula |
C18H19N5O3 |
|
| Molecular Weight (MW) | 353.38 | |
| SMILES | COC1=CC=C(C=C1)C2=NOC(=C2)NC3=NC(=NC=C3)N4CCOCC4 | |
| InChIKey | WRCGBYNVBFVRTN-UHFFFAOYSA-N |
BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3). By targeting TACC3, BO-264 disrupts mitotic spindle stability and specifically blocks the oncogenic function of the FGFR3-TACC3 fusion protein. Suppression of TACC3 activity leads to spindle assembly checkpoint-dependent mitotic arrest, induction of apoptosis, and accumulation of DNA damage, resulting in significant antitumor efficacy in TACC3-dependent cancer models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
71 mg/mL
(200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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