CAS No. 357263-13-9

Batch: Purity:99.75
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BMS-378806 Chemical Structure
Chemical Structure
Check the BMS-378806 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(2R)-4-benzoyl-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione
CAS Number 357263-13-9
Molecular Formula

C22H22N4O4
Molecular Weight (MW) 406.43
SMILES CC1CN(CCN1C(=O)C(=O)C2=CNC3=NC=CC(=C23)OC)C(=O)C4=CC=CC=C4
InChIKey OKGPFTLYBPQBIX-CQSZACIVSA-N

Ordering Information

Biological Activity

BMS-378806 is a small-molecule viral entry inhibitor that selectively targets the HIV-1 envelope glycoprotein gp120, disrupting its interaction with the host CD4 receptor (EC50 range of 0.85–26.5 nM). By preventing gp120-CD4 binding, it blocks downstream viral attachment and host cell entry. It demonstrates specific activity against diverse HIV-1 isolates regardless of chemokine receptor tropism, with no activity against HIV-2 or simian immunodeficiency virus. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 81 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.