CAS No. 215030-90-3
Batch:
Purity:99.44
Chemical Structure
Check the
BMS493
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(E)-2-[5,5-dimethyl-8-(2-phenylethynyl)-6H-naphthalen-2-yl]ethenyl]benzoic acid | |
|---|---|---|
| CAS Number | 215030-90-3 | |
| Molecular Formula |
C29H24O2 |
|
| Molecular Weight (MW) | 404.50 | |
| InChIKey | YCADIXLLWMXYKW-CMDGGOBGSA-N |
Biological Activity
BMS493 is a synthetic inverse agonist of pan retinoic acid receptor (RAR) signaling. By binding RAR isoforms, it enhances nuclear corepressor recruitment, such as NCoR, thereby repressing retinoic acid receptor-mediated transcriptional activation. This suppression disrupts downstream retinoid-dependent gene expression pathways, enabling functional modulation of cell differentiation, organogenesis, and cellular fate in vitro and in vivo. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(215.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.