CAS No. 943962-47-8

Batch: Purity:99.66
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BMS-303141 Chemical Structure
Chemical Structure
Check the BMS-303141 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide
CAS Number 943962-47-8
Molecular Formula

C19H15Cl2NO4S
Molecular Weight (MW) 424.30
SMILES COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=C(C(=CC(=C3)Cl)Cl)O
InChIKey SIIPNDKXZOTLEA-UHFFFAOYSA-N

Ordering Information

Biological Activity

BMS-303141 is a cell-permeable inhibitor of ATP-citrate lyase (ACL) with an IC50 of. By selectively inhibiting ACL, BMS-303141 impairs the catalytic conversion of citrate into acetyl-CoA, a vital precursor for fatty acid and cholesterol biosynthesis. This inhibition disrupts downstream lipogenic pathways, resulting in suppressed cellular lipid accumulation and total lipid synthesis with an IC50 ofin HepG2 cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.